[61] Michigan State 7-49 Iowa [124] 2020-11-07 17:00
Stadium: Kinnick Stadium Round: 1
Head to Head
| NCAAF | 2017/09/30 20:00 | Iowa v Michigan State | W | 10-17 |
| NCAAF | 2015/12/06 01:17 | Iowa v Michigan State | W | 13-16 |
| NCAAF | 2012/10/13 12:00 | Michigan State v Iowa | L | 16-19 |
| NCAAF | 2011/11/12 12:00 | Iowa v Michigan State | W | 21-37 |
| NCAAF | 2010/10/30 12:00 | Iowa v Michigan State | L | 37-6 |
| NCAAF | 2009/10/24 12:00 | Michigan State v Iowa | L | 13-15 |
| NCAAF | 2008/10/04 12:00 | Michigan State v Iowa | W | 16-13 |
| NCAAF | 2007/10/27 12:00 | Iowa v Michigan State | L | 34-27 |
Home History
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | W | 27-24 |
| NCAAF | 2020/10/24 16:00 | Rutgers v Michigan State | L | 38-27 |
| NCAAF | 2019/12/27 20:20 | Michigan State v Wake Forest | W | 27-21 |
| NCAAF | 2019/11/30 20:30 | Maryland v Michigan State | W | 16-19 |
| NCAAF | 2019/11/23 17:00 | Michigan State v Rutgers | W | 27-0 |
| NCAAF | 2019/11/16 17:00 | Michigan State v Michigan | L | 10-44 |
| NCAAF | 2019/11/09 20:30 | Illinois v Michigan State | L | 37-34 |
| NCAAF | 2019/10/26 19:30 | Penn State v Michigan State | L | 28-7 |
Away History
| NCAAF | 2020/10/31 19:30 | Northwestern v Iowa | L | 21-20 |
| NCAAF | 2020/10/24 19:30 | Iowa v Purdue | L | 20-24 |
| NCAAF | 2019/12/28 01:00 | USC v Iowa | W | 24-49 |
| NCAAF | 2019/11/29 19:30 | Iowa v Nebraska | W | 27-24 |
| NCAAF | 2019/11/23 17:00 | Illinois v Iowa | W | 10-19 |
| NCAAF | 2019/11/16 21:00 | Minnesota v Iowa | W | 19-23 |
| NCAAF | 2019/11/09 21:00 | Iowa v Wisconsin | L | 22-24 |
| NCAAF | 2019/10/26 16:00 | Iowa v Northwestern | W | 20-0 |