[15] Northwestern 20-29 Michigan State [97] 2020-11-28 20:30
Stadium: Spartan Stadium Round: 1
Head to Head
| NCAAF | 2019/09/21 16:00 | Michigan State v Northwestern | L | 31-10 |
| NCAAF | 2018/10/06 16:00 | Northwestern v Michigan State | W | 29-19 |
| NCAAF | 2017/10/28 19:30 | Michigan State v Northwestern | W | 31-39 |
| NCAAF | 2016/10/15 19:30 | Northwestern v Michigan State | W | 54-40 |
| NCAAF | 2012/11/17 12:00 | Michigan State v Northwestern | W | 20-23 |
| NCAAF | 2011/11/26 12:00 | Northwestern v Michigan State | L | 17-31 |
| NCAAF | 2010/10/23 12:00 | Northwestern v Michigan State | L | 27-35 |
| NCAAF | 2009/10/17 12:00 | Michigan State v Northwestern | L | 24-14 |
Home History
| NCAAF | 2020/11/21 20:30 | Wisconsin v Northwestern | W | 7-17 |
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | W | 27-20 |
| NCAAF | 2020/11/07 17:00 | Nebraska v Northwestern | W | 13-21 |
| NCAAF | 2020/10/31 19:30 | Northwestern v Iowa | W | 21-20 |
| NCAAF | 2020/10/24 23:30 | Maryland v Northwestern | W | 3-43 |
| NCAAF | 2019/11/30 17:00 | Northwestern v Illinois | W | 29-10 |
| NCAAF | 2019/11/23 17:00 | Minnesota v Northwestern | L | 38-22 |
| NCAAF | 2019/11/16 17:00 | Massachusetts v Northwestern | W | 6-45 |
Away History
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |
| NCAAF | 2020/11/07 17:00 | Michigan State v Iowa | L | 7-49 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | W | 27-24 |
| NCAAF | 2020/10/24 16:00 | Rutgers v Michigan State | L | 38-27 |
| NCAAF | 2019/12/27 20:20 | Michigan State v Wake Forest | W | 27-21 |
| NCAAF | 2019/11/30 20:30 | Maryland v Michigan State | W | 16-19 |
| NCAAF | 2019/11/23 17:00 | Michigan State v Rutgers | W | 27-0 |
| NCAAF | 2019/11/16 17:00 | Michigan State v Michigan | L | 10-44 |