Head to Head
| England League 2 | 2020/10/24 14:00 | Tranmere v Southend | L | 2-0 |
| England League 1 | 2020/01/11 15:00 | Southend v Tranmere | D | 0-0 |
| England League 1 | 2019/10/18 18:45 | Tranmere v Southend | D | 1-1 |
| England League 2 | 2015/04/11 14:00 | Southend v Tranmere | W | 1-0 |
| England League 2 | 2014/11/22 15:00 | Tranmere v Southend | W | 1-2 |
Home History
| England League 2 | 2021/03/06 15:00 | Oldham v Southend | D | 0-0 |
| England League 2 | 2021/03/02 19:00 | Cheltenham v Southend | L | 1-0 |
| England League 2 | 2021/02/27 15:00 | Southend v Salford City | D | 0-0 |
| England League 2 | 2021/02/24 18:00 | Forest Green v Southend | W | 1-3 |
| England League 2 | 2021/02/20 15:00 | Southend v Bolton | L | 0-1 |
| England League 2 | 2021/02/13 15:00 | Cambridge Utd v Southend | D | 0-0 |
| England League 2 | 2021/02/09 19:00 | Newport County v Southend | W | 0-1 |
| England League 2 | 2021/01/30 15:00 | Port Vale v Southend | L | 5-1 |
Away History
| England League 2 | 2021/03/06 15:00 | Tranmere v Crawley Town | L | 0-1 |
| England League 2 | 2021/03/02 19:00 | Tranmere v Newport County | W | 1-0 |
| England League 2 | 2021/02/27 15:00 | Leyton Orient v Tranmere | W | 1-3 |
| England League 2 | 2021/02/23 19:00 | Carlisle v Tranmere | W | 2-3 |
| England League 2 | 2021/02/20 15:00 | Tranmere v Oldham | D | 2-2 |
| England EFL Trophy | 2021/02/16 18:00 | Oxford Utd v Tranmere | W | 0-2 |
| England League 2 | 2021/02/09 19:00 | Tranmere v Stevenage | L | 0-1 |
| England League 2 | 2021/02/06 15:00 | Tranmere v Port Vale | W | 3-1 |