[3] Sale Sharks 25-22 Gloucester [11] 2021-04-17 11:30
Stadium: The AJ Bell Stadium Round: 16
Referee: Adam Leal Home Manager: Paul Deacon Away Manager: George Skivington
Head to Head
| Premiership Rugby | 2021/01/02 16:30 | Gloucester v Sale Sharks | W | 19-22 |
| Premiership Rugby | 2020/02/28 19:45 | Gloucester v Sale Sharks | W | 17-23 |
| Premiership Rugby | 2019/10/19 14:00 | Sale Sharks v Gloucester | L | 16-18 |
| Premiership Rugby | 2019/05/18 15:00 | Sale Sharks v Gloucester | W | 46-41 |
| Premiership Rugby | 2018/12/29 15:00 | Gloucester v Sale Sharks | W | 15-30 |
| Premiership Rugby | 2017/12/30 15:00 | Gloucester v Sale Sharks | L | 20-16 |
| Premiership Rugby | 2017/09/29 19:00 | Sale Sharks v Gloucester | W | 57-10 |
| Premiership Rugby | 2017/04/15 14:00 | Gloucester v Sale Sharks | L | 39-30 |
Home History
| European Rugby Champions Cup | 2021/04/10 14:00 | La Rochelle v Sale Sharks | L | 45-21 |
| European Rugby Champions Cup | 2021/04/04 16:30 | Scarlets v Sale Sharks | W | 14-57 |
| Premiership Rugby | 2021/03/27 16:30 | Wasps v Sale Sharks | W | 19-20 |
| Premiership Rugby | 2021/03/21 15:00 | Sale Sharks v London Irish | W | 41-13 |
| Premiership Rugby | 2021/03/13 14:45 | Northampton v Sale Sharks | L | 17-14 |
| Premiership Rugby | 2021/03/05 20:00 | Sale Sharks v Newcastle Falcons | W | 31-16 |
| Premiership Rugby | 2021/02/26 19:45 | Sale Sharks v Exeter Chiefs | W | 25-20 |
| Premiership Rugby | 2021/02/20 13:00 | Harlequins v Sale Sharks | L | 24-12 |
Away History
| European Rugby Champions Cup | 2021/04/02 19:00 | Gloucester v La Rochelle | L | 16-27 |
| Premiership Rugby | 2021/03/26 17:30 | Gloucester v Exeter Chiefs | W | 34-18 |
| Premiership Rugby | 2021/03/20 14:00 | Harlequins v Gloucester | L | 59-24 |
| Premiership Rugby | 2021/03/13 15:00 | Gloucester v Leicester | L | 14-20 |
| Premiership Rugby | 2021/03/06 15:00 | Wasps v Gloucester | W | 19-20 |
| Premiership Rugby | 2021/02/27 15:15 | Gloucester v Worcester Warriors | W | 22-14 |
| Premiership Rugby | 2021/02/19 19:45 | Bath v Gloucester | L | 16-14 |
| Premiership Rugby | 2021/02/12 19:45 | Gloucester v Bristol | L | 17-18 |