[10] Northampton 29-49 Harlequins [12] 2020-11-28 14:00
Stadium: Franklin's Gardens Round: 2
Referee: Tom Foley Home Manager: Chris Boyd Away Manager: Paul Gustard
Head to Head
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | L | 30-17 |
| Premiership Rugby | 2019/11/01 19:45 | Northampton v Harlequins | W | 40-22 |
| Premiership Rugby | 2019/04/13 14:00 | Harlequins v Northampton | W | 19-20 |
| Premiership Rugby | 2018/09/07 18:45 | Northampton v Harlequins | W | 25-18 |
| LV Cup | 2018/02/02 19:45 | Northampton v Harlequins | W | 36-10 |
| Premiership Rugby | 2017/12/30 16:00 | Harlequins v Northampton | L | 50-21 |
| Premiership Rugby | 2017/09/30 14:00 | Northampton v Harlequins | W | 30-22 |
| Premiership Rugby | 2017/05/06 15:00 | Northampton v Harlequins | W | 22-20 |
Home History
| Premiership Rugby | 2020/11/20 20:00 | Sale Sharks v Northampton | L | 32-23 |
| Premiership Rugby | 2020/09/29 16:30 | Northampton v Sale Sharks | L | 14-34 |
| European Rugby Champions Cup | 2020/09/20 16:30 | Exeter Chiefs v Northampton | L | 38-15 |
| Premiership Rugby | 2020/09/13 13:00 | Leicester v Northampton | L | 28-24 |
| Premiership Rugby | 2020/09/08 18:45 | Bristol v Northampton | L | 47-10 |
| Premiership Rugby | 2020/09/04 18:45 | Northampton v Exeter Chiefs | L | 19-22 |
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | L | 30-17 |
| Premiership Rugby | 2020/08/26 18:45 | Northampton v Bath | L | 3-18 |
Away History
| Premiership Rugby | 2020/11/20 19:45 | Harlequins v Exeter Chiefs | L | 3-33 |
| Premiership Rugby | 2020/10/04 14:00 | Leicester v Harlequins | W | 26-32 |
| Premiership Rugby | 2020/09/28 18:45 | Harlequins v Wasps | L | 23-32 |
| Premiership Rugby Cup | 2020/09/21 18:45 | Sale Sharks v Harlequins | L | 27-19 |
| Premiership Rugby | 2020/09/14 18:45 | Gloucester v Harlequins | W | 15-28 |
| Premiership Rugby | 2020/09/09 18:45 | London Irish v Harlequins | W | 15-38 |
| Premiership Rugby | 2020/09/05 13:00 | Harlequins v Bath | L | 27-41 |
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | W | 30-17 |