[4] Harlequins 37-19 Northampton [5] 2021-03-07 15:00
Stadium: London Round: 12
Referee: Luke Pearce Home Manager: Paul Gustard Away Manager: Chris Boyd
Head to Head
| Premiership Rugby | 2020/11/28 14:00 | Northampton v Harlequins | W | 29-49 |
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | W | 30-17 |
| Premiership Rugby | 2019/11/01 19:45 | Northampton v Harlequins | L | 40-22 |
| Premiership Rugby | 2019/04/13 14:00 | Harlequins v Northampton | L | 19-20 |
| Premiership Rugby | 2018/09/07 18:45 | Northampton v Harlequins | L | 25-18 |
| LV Cup | 2018/02/02 19:45 | Northampton v Harlequins | L | 36-10 |
| Premiership Rugby | 2017/12/30 16:00 | Harlequins v Northampton | W | 50-21 |
| Premiership Rugby | 2017/09/30 14:00 | Northampton v Harlequins | L | 30-22 |
Home History
| Premiership Rugby | 2021/02/27 15:00 | Newcastle Falcons v Harlequins | L | 25-22 |
| Premiership Rugby | 2021/02/20 13:00 | Harlequins v Sale Sharks | W | 24-12 |
| Premiership Rugby | 2021/02/13 16:00 | Harlequins v Leicester | W | 37-24 |
| Premiership Rugby | 2021/02/06 14:15 | Bath v Harlequins | W | 15-28 |
| Premiership Rugby | 2021/01/31 15:00 | Wasps v Harlequins | W | 17-49 |
| Premiership Rugby | 2021/01/10 15:00 | Harlequins v London Irish | D | 27-27 |
| Premiership Rugby | 2020/12/26 14:00 | Harlequins v Bristol | L | 19-27 |
| European Rugby Champions Cup | 2020/12/20 15:15 | Harlequins v Racing Metro | L | 7-49 |
Away History
| Premiership Rugby | 2021/02/28 13:00 | Northampton v Bath | L | 22-23 |
| Premiership Rugby | 2021/02/20 15:00 | Exeter Chiefs v Northampton | W | 12-13 |
| Premiership Rugby | 2021/02/06 13:00 | Wasps v Northampton | W | 17-22 |
| Premiership Rugby | 2021/01/30 15:00 | Gloucester v Northampton | W | 26-31 |
| Premiership Rugby | 2020/12/26 16:30 | Northampton v Worcester Warriors | W | 29-10 |
| European Rugby Champions Cup | 2020/12/19 13:00 | Leinster v Northampton | L | 35-19 |
| European Rugby Champions Cup | 2020/12/11 17:30 | Northampton v Bordeaux | L | 12-16 |
| Premiership Rugby | 2020/12/04 19:45 | Bristol v Northampton | L | 18-17 |