[9] Leyton Orient 2-4 Cambridge Utd [1] 2021-04-20 18:00
Stadium: Matchroom Stadium Round: 43
Referee: Christopher Pollard Home Manager: Joel Joshua Frederick McAnuff Away Manager: Mark Bonner
Head to Head
| England League 2 | 2020/12/26 13:00 | Cambridge Utd v Leyton Orient | L | 2-1 |
| England League 2 | 2020/03/07 15:00 | Leyton Orient v Cambridge Utd | W | 2-1 |
| England League 2 | 2019/12/21 15:00 | Cambridge Utd v Leyton Orient | W | 2-3 |
| England League 2 | 2017/04/08 14:00 | Cambridge Utd v Leyton Orient | L | 3-0 |
| England League 2 | 2016/12/31 13:00 | Leyton Orient v Cambridge Utd | D | 1-1 |
| England League 2 | 2016/01/30 15:00 | Leyton Orient v Cambridge Utd | L | 1-3 |
| England League 2 | 2015/09/12 14:00 | Cambridge Utd v Leyton Orient | D | 1-1 |
Home History
| England League 2 | 2021/04/17 11:30 | Leyton Orient v Barrow | W | 2-0 |
| England League 2 | 2021/04/13 18:00 | Harrogate Town v Leyton Orient | D | 2-2 |
| England League 2 | 2021/04/10 14:00 | Cheltenham v Leyton Orient | L | 1-0 |
| England League 2 | 2021/04/05 14:00 | Leyton Orient v Walsall | D | 0-0 |
| England League 2 | 2021/04/02 14:00 | Mansfield v Leyton Orient | W | 0-2 |
| England League 2 | 2021/03/27 15:00 | Leyton Orient v Oldham | W | 2-1 |
| England League 2 | 2021/03/23 18:30 | Carlisle v Leyton Orient | W | 0-1 |
| England League 2 | 2021/03/20 13:00 | Newport County v Leyton Orient | W | 0-1 |
Away History
| England League 2 | 2021/04/17 11:30 | Newport County v Cambridge Utd | W | 0-1 |
| England League 2 | 2021/04/10 14:00 | Cambridge Utd v Exeter | L | 1-4 |
| England League 2 | 2021/04/05 14:00 | Tranmere v Cambridge Utd | D | 1-1 |
| England League 2 | 2021/04/02 14:00 | Cambridge Utd v Morecambe | W | 2-1 |
| England League 2 | 2021/03/27 15:00 | Carlisle v Cambridge Utd | W | 1-2 |
| England League 2 | 2021/03/20 15:00 | Cambridge Utd v Forest Green | W | 1-0 |
| England League 2 | 2021/03/13 15:00 | Oldham v Cambridge Utd | W | 2-4 |
| England League 2 | 2021/03/09 19:00 | Bolton v Cambridge Utd | L | 2-1 |