[54] Wake Forest 21-45 Louisville [81] 2020-12-12 17:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Head to Head
| NCAAF | 2019/10/12 23:30 | Louisville v Wake Forest | L | 62-59 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | W | 56-35 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | W | 32-42 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | L | 12-44 |
| NCAAF | 2015/10/30 23:00 | Wake Forest v Louisville | L | 19-20 |
| NCAAF | 2014/09/27 19:30 | Louisville v Wake Forest | L | 20-10 |
| NCAAF Bowl Games | 2007/01/02 12:00 | Louisville v Wake Forest | L | 24-13 |
Home History
| NCAAF | 2020/11/14 17:00 | Wake Forest v North Carolina | L | 53-59 |
| NCAAF | 2020/10/31 16:00 | Wake Forest v Syracuse | W | 38-14 |
| NCAAF | 2020/10/24 19:30 | Virginia Tech v Wake Forest | W | 16-23 |
| NCAAF | 2020/10/17 20:00 | Virginia v Wake Forest | W | 23-40 |
| NCAAF | 2020/10/02 23:00 | Campbell v Wake Forest | W | 14-66 |
| NCAAF | 2020/09/20 00:00 | Wake Forest v NC State | L | 42-45 |
| NCAAF | 2020/09/12 23:30 | Clemson v Wake Forest | L | 37-13 |
| NCAAF | 2019/12/27 20:20 | Michigan State v Wake Forest | L | 27-21 |
Away History
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |
| NCAAF | 2020/10/17 18:30 | Louisville v Notre Dame | L | 7-12 |
| NCAAF | 2020/10/09 23:00 | Louisville v Georgia Tech | L | 27-46 |
| NCAAF | 2020/09/26 16:00 | Louisville v Pittsburgh | L | 20-23 |