Head to Head
| Ghana Premier League | 2020/12/27 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2020/01/15 15:00 | Medeama SC v Asante Kotoko | L | 1-0 |
| Ghana Premier League | 2018/03/28 15:00 | Medeama SC v Asante Kotoko | L | 1-0 |
| Ghana FA Cup | 2017/10/02 15:00 | Asante Kotoko v Medeama SC | W | 1-0 |
| Ghana FA Cup | 2017/10/01 18:00 | Asante Kotoko v Medeama SC | D | 0-0 |
| Ghana Premier League | 2017/07/09 15:00 | Asante Kotoko v Medeama SC | W | 3-1 |
| Ghana Premier League | 2017/04/05 15:00 | Medeama SC v Asante Kotoko | L | 2-1 |
| Ghana Premier League | 2016/09/11 15:15 | Medeama SC v Asante Kotoko | D | 1-1 |
Home History
| Ghana Premier League | 2021/04/16 15:00 | Great Olympics v Asante Kotoko | D | 0-0 |
| Ghana Premier League | 2021/04/11 15:00 | Asante Kotoko v Berekum Chelsea | W | 2-0 |
| Ghana Premier League | 2021/04/07 15:00 | Asante Kotoko v Bechem FC | W | 4-0 |
| Ghana Premier League | 2021/04/03 15:00 | Eleven Wonders v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2021/03/10 15:00 | King Faisal v Asante Kotoko | W | 0-1 |
| Ghana Premier League | 2021/03/05 18:00 | Elmina Sharks v Asante Kotoko | L | 1-0 |
| Ghana Premier League | 2021/02/28 15:00 | Asante Kotoko v Hearts of Oak | D | 0-0 |
| CAF Confederations Cup | 2021/02/21 17:00 | ES Setif v Asante Kotoko | D | 0-0 |
Away History
| Ghana Premier League | 2021/04/18 15:00 | Medeama SC v Legon Cities FC | W | 2-1 |
| Ghana Premier League | 2021/04/11 15:00 | Medeama SC v Dreams | W | 2-0 |
| Ghana Premier League | 2021/04/02 15:00 | Great Olympics v Medeama SC | L | 1-0 |
| Ghana Premier League | 2021/03/07 15:00 | Berekum Chelsea v Medeama SC | D | 1-1 |
| Ghana Premier League | 2021/02/24 15:00 | Medeama SC v Eleven Wonders | W | 2-0 |
| Ghana Premier League | 2021/02/21 15:00 | Elmina Sharks v Medeama SC | W | 1-2 |
| Ghana Premier League | 2021/02/14 15:00 | Medeama SC v Bechem FC | W | 2-0 |
| Ghana Premier League | 2021/02/09 15:00 | King Faisal v Medeama SC | L | 1-0 |