[31] BUF Sabres 2-5 NY Islanders [6] 2021-03-07 17:00
Stadium: Nassau Veterans Memorial Coliseum
Home Manager: Barry Trotz Away Manager: Ralph Krueger
Head to Head
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | L | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL | 2019/12/14 18:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2019/11/02 23:00 | NY Islanders v BUF Sabres | L | 1-0 |
| NHL | 2019/03/30 23:00 | BUF Sabres v NY Islanders | L | 1-5 |
Home History
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/03 00:00 | BUF Sabres v NY Rangers | L | 2-3 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | L | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | L | 3-0 |
| NHL | 2021/02/26 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/02/24 00:00 | BUF Sabres v NJ Devils | W | 4-1 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | L | 2-3 |
Away History
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/03 00:00 | NY Islanders v NJ Devils | W | 2-1 |
| NHL | 2021/02/28 22:00 | PIT Penguins v NY Islanders | W | 0-2 |
| NHL | 2021/02/28 00:00 | PIT Penguins v NY Islanders | L | 4-3 |
| NHL | 2021/02/26 00:00 | BOS Bruins v NY Islanders | W | 2-7 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2021/02/21 00:00 | NY Islanders v PIT Penguins | L | 2-3 |