[10] Penarol 1-2 Defensor Sporting [9] 2021-01-28 00:00
Stadium: Estadio Campeon del Siglo Round: 2
Referee: Christian Ferreyra Home Manager: Mauricio Larriera Away Manager: Gregorio Elso Perez Perdigon
Head to Head
| Uruguay Torneo Intermedio | 2020/11/01 21:00 | Defensor Sporting v Penarol | L | 2-1 |
| Uruguay Apertura | 2020/02/23 22:30 | Defensor Sporting v Penarol | L | 2-1 |
| Uruguay Clausura | 2019/09/14 22:00 | Penarol v Defensor Sporting | W | 1-0 |
| Uruguay Torneo Intermedio | 2019/08/11 21:00 | Defensor Sporting v Penarol | D | 2-2 |
| Uruguay Apertura | 2019/02/17 22:30 | Defensor Sporting v Penarol | W | 0-1 |
| Uruguay Clausura | 2018/11/04 19:30 | Defensor Sporting v Penarol | W | 1-2 |
| Uruguay Torneo Intermedio | 2018/06/07 18:00 | Defensor Sporting v Penarol | W | 1-3 |
| Uruguay Apertura | 2018/05/05 18:30 | Penarol v Defensor Sporting | W | 4-1 |
Home History
| Uruguay Clausura | 2021/01/16 20:00 | Cerro v Penarol | D | 1-1 |
| Uruguay Torneo Intermedio | 2020/12/19 20:00 | Danubio v Penarol | W | 1-4 |
| Uruguay Torneo Intermedio | 2020/12/13 20:30 | Penarol v Nacional De Football | W | 3-2 |
| Uruguay Torneo Intermedio | 2020/11/22 22:30 | Penarol v Boston River | W | 2-0 |
| Uruguay Torneo Intermedio | 2020/11/11 19:30 | Atletico Fenix Montevideo v Penarol | L | 1-0 |
| Uruguay Torneo Intermedio | 2020/11/08 21:00 | Penarol v Deportivo Maldonado | W | 4-1 |
| Copa Sudamericana | 2020/11/05 00:30 | Penarol v Velez Sarsfield | D | 1-1 |
| Uruguay Torneo Intermedio | 2020/11/01 21:00 | Defensor Sporting v Penarol | L | 2-1 |
Away History
| Uruguay Clausura | 2021/01/18 00:45 | Defensor Sporting v Montevideo Wanderers | D | 1-1 |
| Uruguay Torneo Intermedio | 2021/01/13 21:00 | Defensor Sporting v Boston River | D | 1-1 |
| Uruguay Torneo Intermedio | 2020/11/29 20:00 | CA River Plate v Defensor Sporting | D | 1-1 |
| Uruguay Torneo Intermedio | 2020/11/22 00:45 | Defensor Sporting v Atletico Fenix Montevideo | L | 0-1 |
| Uruguay Torneo Intermedio | 2020/11/11 21:45 | Deportivo Maldonado v Defensor Sporting | L | 3-1 |
| Uruguay Torneo Intermedio | 2020/11/07 21:00 | Nacional De Football v Defensor Sporting | L | 3-0 |
| Uruguay Torneo Intermedio | 2020/11/01 21:00 | Defensor Sporting v Penarol | W | 2-1 |
| Uruguay Torneo Intermedio | 2020/10/18 18:00 | Danubio v Defensor Sporting | D | 0-0 |