[4] Daniil Medvedev 6-2,6-4 Kei Nishikori [41] 2021-02-03 08:00
Stadium: John Cain Arena Round: 2 Ground: Hardcourt outdoor
Head to Head
| ATP Barcelona | 2019/04/27 11:30 | Kei Nishikori v Daniil Medvedev | 4-6,6-3,5-7 |
| ATP Brisbane | 2019/01/06 09:30 | Daniil Medvedev v Kei Nishikori | 4-6,6-3,2-6 |
| ATP Tokyo | 2018/10/07 06:30 | Daniil Medvedev v Kei Nishikori | 6-2,6-4 |
| ATP Monte Carlo | 2018/04/18 09:00 | Daniil Medvedev v Kei Nishikori | 5-7,2-6 |
Home History
| ATP Cup | 2021/02/02 08:00 | Daniil Medvedev v Diego Schwartzman | 7-5,6-3 |
| ATP World Tour Finals | 2020/11/22 18:00 | Daniil Medvedev v Dominic Thiem | 4-6,7-6,6-4 |
| ATP World Tour Finals | 2020/11/21 20:05 | Daniil Medvedev v Rafael Nadal | 3-6,7-6,6-3 |
| ATP World Tour Finals | 2020/11/20 20:00 | Daniil Medvedev v Diego Schwartzman | 6-3,6-3 |
| ATP World Tour Finals | 2020/11/18 20:00 | Novak Djokovic v Daniil Medvedev | 3-6,3-6 |
| ATP World Tour Finals | 2020/11/16 20:00 | Daniil Medvedev v Alexander Zverev | 6-3,6-4 |
| ATP Paris | 2020/11/08 14:00 | Alexander Zverev v Daniil Medvedev | 7-5,4-6,1-6 |
| ATP Paris | 2020/11/07 13:00 | Daniil Medvedev v Milos Raonic | 6-4,7-6 |
Away History
| French Open | 2020/09/30 13:20 | Kei Nishikori v Stefano Travaglia | 4-6,6-2,6-7,6-4,2-6 |
| French Open | 2020/09/27 10:35 | Daniel Evans v Kei Nishikori | 6-1,1-6,6-7,6-1,4-6 |
| ATP Hamburg | 2020/09/22 08:00 | Cristian Garin v Kei Nishikori | 6-0,6-3 |
| ATP Rome | 2020/09/17 18:30 | Lorenzo Musetti v Kei Nishikori | 6-3,6-4 |
| ATP Rome | 2020/09/14 16:50 | Kei Nishikori v Albert Ramos-Vinolas | 6-4,7-6 |
| ATP Kitzbuhel | 2020/09/08 13:30 | Miomir Kecmanovic v Kei Nishikori | 4-6,6-4,6-2 |
| US Open | 2019/08/30 15:00 | Alex De Minaur v Kei Nishikori | 6-2,6-4,2-6,6-3 |
| US Open | 2019/08/28 15:00 | Bradley Klahn v Kei Nishikori | 2-6,6-4,3-6,5-7 |