[30] BUF Sabres 2-3 NY Islanders [17] 2021-02-23 00:00
Stadium: Nassau Veterans Memorial Coliseum
Home Manager: Barry Trotz Away Manager: Ralph Krueger
Head to Head
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | L | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL | 2019/12/14 18:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2019/11/02 23:00 | NY Islanders v BUF Sabres | L | 1-0 |
| NHL | 2019/03/30 23:00 | BUF Sabres v NY Islanders | L | 1-5 |
| NHL | 2019/02/13 00:00 | NY Islanders v BUF Sabres | W | 1-3 |
| NHL | 2018/12/31 23:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL Pre-Season | 2018/09/28 23:00 | BUF Sabres v NY Islanders | W | 5-4 |
Home History
| NHL | 2021/02/20 17:30 | BUF Sabres v NJ Devils | W | 3-2 |
| NHL | 2021/02/19 00:00 | BUF Sabres v WAS Capitals | L | 1-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | L | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL | 2021/01/31 18:00 | NJ Devils v BUF Sabres | L | 5-3 |
| NHL | 2021/01/30 18:00 | NJ Devils v BUF Sabres | W | 3-4 |
| NHL | 2021/01/29 00:00 | NY Rangers v BUF Sabres | L | 3-2 |
| NHL | 2021/01/27 00:00 | NY Rangers v BUF Sabres | W | 2-3 |
Away History
| NHL | 2021/02/21 00:00 | NY Islanders v PIT Penguins | L | 2-3 |
| NHL | 2021/02/19 00:00 | NY Islanders v PIT Penguins | L | 1-4 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | W | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-1 |
| NHL | 2021/02/14 00:00 | BOS Bruins v NY Islanders | W | 2-4 |
| NHL | 2021/02/12 00:00 | PIT Penguins v NY Islanders | L | 4-3 |
| NHL | 2021/02/09 00:00 | NY Islanders v NY Rangers | W | 2-0 |
| NHL | 2021/02/07 00:00 | PIT Penguins v NY Islanders | W | 3-4 |