[3] Colon 2-0 San Lorenzo [5] 2021-02-23 00:30
Stadium: Estadio Brigadier Estanislao Lopez Round: 2
Referee: Patricio Hernan Loustau Home Manager: Eduardo Dominguez Away Manager: Diego Dabove
Head to Head
| Argentina Copa de la Liga Profesional | 2020/12/19 22:20 | San Lorenzo v Colon | D | 2-2 |
| Argentina Superliga | 2019/09/14 20:45 | Colon v San Lorenzo | W | 2-1 |
| Argentina Superliga | 2019/03/23 23:00 | Colon v San Lorenzo | D | 1-1 |
| Argentina Cup | 2018/09/08 00:10 | San Lorenzo v Colon | L | 5-3 |
| Argentina Superliga | 2017/09/30 17:05 | San Lorenzo v Colon | D | 0-0 |
| Argentina Superliga | 2017/06/16 00:30 | Colon v San Lorenzo | W | 2-1 |
| Argentina Liga Profesional | 2016/05/14 18:30 | Colon v San Lorenzo | L | 0-2 |
| Argentina Liga Profesional | 2015/02/14 20:00 | San Lorenzo v Colon | L | 2-0 |
Home History
| Argentina Copa de la Liga Profesional | 2021/02/13 00:30 | Central Cordoba v Colon | W | 0-3 |
| Argentina Cup | 2021/01/15 00:10 | Colon v Cipolletti | W | 1-0 |
| Argentina Copa de la Liga Profesional | 2021/01/11 00:30 | Colon v CA Talleres de Córdoba | L | 1-2 |
| Argentina Copa de la Liga Profesional | 2021/01/06 00:30 | Atlético Tucumán v Colon | W | 0-2 |
| Argentina Copa de la Liga Profesional | 2020/12/29 00:30 | Colon v Banfield | L | 1-2 |
| Argentina Copa de la Liga Profesional | 2020/12/19 22:20 | San Lorenzo v Colon | D | 2-2 |
| Argentina Copa de la Liga Profesional | 2020/12/12 20:10 | Colon v Gimnasia LP | L | 0-2 |
| Argentina Copa de la Liga Profesional | 2020/12/04 22:20 | Central Cordoba v Colon | W | 0-2 |
Away History
| Argentina Cup | 2021/02/19 00:10 | San Lorenzo v Deportivo Liniers | W | 3-0 |
| Argentina Copa de la Liga Profesional | 2021/02/14 00:30 | San Lorenzo v Arsenal de Sarandi | W | 2-1 |
| Argentina Copa de la Liga Profesional | 2021/01/11 00:30 | Banfield v San Lorenzo | L | 4-1 |
| Argentina Copa de la Liga Profesional | 2021/01/04 22:20 | San Lorenzo v Gimnasia LP | L | 1-2 |
| Argentina Copa de la Liga Profesional | 2020/12/30 00:30 | Atlético Tucumán v San Lorenzo | W | 1-3 |
| Argentina Copa de la Liga Profesional | 2020/12/19 22:20 | San Lorenzo v Colon | D | 2-2 |
| Argentina Copa de la Liga Profesional | 2020/12/13 00:30 | San Lorenzo v CA Talleres de Córdoba | L | 0-2 |
| Argentina Copa de la Liga Profesional | 2020/12/07 22:10 | San Lorenzo v CA Aldosivi | D | 0-0 |