[7] Aryna Sabalenka 4-6,6-2,4-6 Serena Williams [11] 2021-02-14 02:15
Stadium: Rod Laver Arena Round: 26 Ground: Hardcourt outdoor
Home History
| Australian Open Women | 2021/02/12 00:00 | Aryna Sabalenka v Ann Li | 6-3,6-1 |
| Australian Open Women | 2021/02/10 00:00 | Aryna Sabalenka v Daria Kasatkina | 7-6,6-3 |
| Australian Open Women | 2021/02/08 09:05 | Aryna Sabalenka v Viktoria Hruncakova | 6-0,6-4 |
| WTA Gippsland Trophy | 2021/02/02 01:25 | Aryna Sabalenka v Kaia Kanepi | 1-6,6-2,1-6 |
| WTA Abu Dhabi | 2021/01/13 08:00 | Aryna Sabalenka v Veronika Kudermetova | 6-2,6-2 |
| WTA Abu Dhabi | 2021/01/12 08:00 | Maria Sakkari v Aryna Sabalenka | 3-6,2-6 |
| WTA Abu Dhabi | 2021/01/11 06:00 | Aryna Sabalenka v Elena Rybakina | 6-4,4-6,6-3 |
| WTA Abu Dhabi | 2021/01/10 06:00 | Aryna Sabalenka v Ons Jabeur | 6-2,6-4 |
Away History
| Australian Open Women | 2021/02/12 02:00 | Anastasia Potapova v Serena Williams | 6-7,2-6 |
| Australian Open Women | 2021/02/10 02:00 | Nina Stojanovic v Serena Williams | 3-6,0-6 |
| Australian Open Women | 2021/02/08 01:30 | Laura Siegemund v Serena Williams | 1-6,1-6 |
| WTA Yarra Valley Classic | 2021/02/05 02:20 | Danielle Rose Collins v Serena Williams | 2-6,6-4,6-10 |
| WTA Yarra Valley Classic | 2021/02/03 07:30 | Tsvetana Pironkova v Serena Williams | 1-6,4-6 |
| WTA Yarra Valley Classic | 2021/02/01 06:00 | Daria Saville v Serena Williams | 1-6,4-6 |
| A Day At The Drive | 2021/01/29 04:00 | Serena Williams v Naomi Osaka | 6-2,2-6,1-0 |
| French Open Women | 2020/09/28 13:05 | Kristie Ahn v Serena Williams | 6-7,0-6 |