[139] Mackenzie McDonald 6-2,6-3 Denis Istomin [195] 2021-02-24 10:00
Stadium: Center Court Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP New York | 2019/02/13 16:00 | Denis Istomin v Mackenzie McDonald | 4-6,6-2,6-3 |
| ATP Cincinnati Qual | 2017/08/12 21:40 | Mackenzie McDonald v Denis Istomin | 6-4,6-2 |
Home History
| Challenger Nur-Sultan | 2021/02/22 13:00 | Mikhail Kukushkin v Mackenzie McDonald | 5-7,5-7 |
| Australian Open | 2021/02/15 01:50 | Mackenzie McDonald v Daniil Medvedev | 4-6,2-6,3-6 |
| Australian Open | 2021/02/13 01:55 | Lloyd Harris v Mackenzie McDonald | 6-7,1-6,4-6 |
| Australian Open | 2021/02/11 04:25 | Mackenzie McDonald v Borna Coric | 6-4,6-2,4-6,6-4 |
| Australian Open | 2021/02/09 00:00 | Mackenzie McDonald v Marco Cecchinato | 3-6,6-3,6-2,6-2 |
| ATP Murray River Open | 2021/02/03 00:00 | Alex Bolt v Mackenzie McDonald | 6-4,6-7,7-5 |
| ATP Murray River Open | 2021/02/01 02:35 | Mackenzie McDonald v Richard Gasquet | 7-6,7-5 |
| ATP Delray Beach | 2021/01/08 01:00 | Mackenzie McDonald v Sam Querrey | 3-6,4-6 |
Away History
| Challenger Nur-Sultan | 2021/02/23 06:00 | Denis Istomin v Denis Yevseyev | 6-7,6-3,6-3 |
| Challenger Cherbourg | 2021/02/11 11:15 | Ruben Bemelmans v Denis Istomin | 6-4,7-6 |
| Challenger Cherbourg | 2021/02/10 10:00 | Denis Istomin v Nathaniel Lammons | 6-3,5-7,6-4 |
| Challenger Quimper | 2021/02/02 11:00 | Tobias Kamke v Denis Istomin | 5-7,6-4,6-4 |
| Challenger Quimper | 2021/01/27 18:50 | Constant Lestienne v Denis Istomin | 6-4,6-4 |
| Challenger Quimper | 2021/01/25 12:30 | Lukas Lacko v Denis Istomin | 3-6,7-6,6-7 |
| Challenger Istanbul | 2021/01/20 07:00 | Marc-Andrea Huesler v Denis Istomin | 2-6,6-2,6-4 |
| Challenger Istanbul | 2021/01/18 08:15 | Denis Istomin v Jay Clarke | 6-7,6-3,4-6 |