[31] BUF Sabres 3-6 NY Rangers [14] 2021-04-25 22:00
Stadium: Madison Square Garden
Home Manager: David Quinn Away Manager: Don Granato
Head to Head
| NHL | 2021/04/03 23:00 | NY Rangers v BUF Sabres | W | 2-3 |
| NHL | 2021/04/01 23:00 | NY Rangers v BUF Sabres | L | 3-2 |
| NHL | 2021/03/22 23:00 | BUF Sabres v NY Rangers | L | 3-5 |
| NHL | 2021/03/03 00:00 | BUF Sabres v NY Rangers | L | 2-3 |
| NHL | 2021/01/29 00:00 | NY Rangers v BUF Sabres | L | 3-2 |
| NHL | 2021/01/27 00:00 | NY Rangers v BUF Sabres | W | 2-3 |
| NHL | 2020/02/08 00:00 | BUF Sabres v NY Rangers | W | 3-2 |
| NHL | 2019/10/24 23:00 | BUF Sabres v NY Rangers | L | 2-6 |
Home History
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | W | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | L | 2-0 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | W | 2-4 |
| NHL | 2021/04/17 19:00 | PIT Penguins v BUF Sabres | L | 3-2 |
| NHL | 2021/04/15 23:00 | BUF Sabres v WAS Capitals | W | 5-2 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | L | 2-3 |
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | W | 5-3 |
Away History
| NHL | 2021/04/23 23:00 | PHI Flyers v NY Rangers | W | 1-4 |
| NHL | 2021/04/22 23:00 | PHI Flyers v NY Rangers | L | 3-2 |
| NHL | 2021/04/20 23:00 | NY Rangers v NY Islanders | L | 1-6 |
| NHL | 2021/04/18 19:00 | NY Rangers v NJ Devils | W | 5-3 |
| NHL | 2021/04/17 16:30 | NJ Devils v NY Rangers | W | 3-6 |
| NHL | 2021/04/15 23:00 | NJ Devils v NY Rangers | W | 0-4 |
| NHL | 2021/04/13 23:00 | NY Rangers v NJ Devils | W | 3-0 |
| NHL | 2021/04/11 23:00 | NY Rangers v NY Islanders | L | 2-3 |