Murray State 24-21 SE Missouri State 2021-03-07 20:00
Stadium: Houck Stadium Round: 1
Head to Head
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | L | 24-31 |
| NCAAF FCS | 2018/11/10 17:00 | SE Missouri St v Murray State | W | 38-40 |
| NCAAF | 2017/11/18 19:00 | SE Missouri St v Murray State | L | 21-10 |
Home History
| NCAAF | 2021/02/28 20:00 | Tennessee Martin v Murray State | W | 10-14 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | L | 24-31 |
| NCAAF | 2019/11/16 18:00 | Austin Peay v Murray State | L | 42-7 |
| NCAAF | 2019/11/02 18:00 | Tennessee Tech v Murray State | L | 17-7 |
| NCAAF | 2019/10/26 20:00 | Murray State v Jacksonville State | L | 12-14 |
| NCAAF | 2019/10/19 19:00 | Eastern Kentucky v Murray State | L | 34-27 |
| NCAAF | 2019/10/12 19:00 | Murray State v Tennessee State | W | 31-17 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | W | 17-24 |
Away History
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | W | 7-47 |
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | L | 17-20 |
| NCAAF | 2019/11/30 19:00 | Illinois State v SE Missouri St | L | 24-6 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | W | 24-31 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | W | 26-12 |
| NCAAF | 2019/11/09 19:00 | Eastern Kentucky v SE Missouri St | W | 31-38 |
| NCAAF | 2019/11/02 19:00 | SE Missouri St v Tennessee State | W | 32-13 |
| NCAAF | 2019/10/26 18:00 | Tennessee Martin v SE Missouri St | W | 10-17 |