Stadium: Enterprise Center Round: 3
Home Manager: Porter Moser Away Manager: Bryan Mullins
| NCAAB | 2021/02/27 23:00 | Southern Illinois v Loyola Chicago | L | 58-65 |
| NCAAB | 2021/02/27 02:00 | Southern Illinois v Loyola Chicago | L | 52-60 |
| NCAAB | 2020/01/30 01:00 | Loyola Chicago v Southern Illinois | W | 63-68 |
| NCAAB | 2020/01/17 01:00 | Southern Illinois v Loyola Chicago | L | 48-64 |
| NCAAB | 2019/02/24 21:00 | Loyola Chicago v Southern Illinois | W | 53-63 |
| NCAAB | 2019/01/27 21:00 | Southern Illinois v Loyola Chicago | L | 50-75 |
| NCAAB | 2018/02/22 01:00 | Loyola Chicago v Southern Illinois | L | 75-56 |
| NCAAB | 2018/01/18 01:00 | Southern Illinois v Loyola Chicago | L | 65-79 |
| NCAAB | 2021/03/04 23:00 | Southern Illinois v Bradley | W | 73-63 |
| NCAAB | 2021/02/27 23:00 | Southern Illinois v Loyola Chicago | L | 58-65 |
| NCAAB | 2021/02/27 02:00 | Southern Illinois v Loyola Chicago | L | 52-60 |
| NCAAB | 2021/02/23 00:00 | Valparaiso v Southern Illinois | W | 64-67 |
| NCAAB | 2021/02/21 22:00 | Valparaiso v Southern Illinois | L | 66-65 |
| NCAAB | 2021/02/18 02:15 | Missouri State v Southern Illinois | L | 68-53 |
| NCAAB | 2021/02/14 21:00 | Illinois St v Southern Illinois | W | 49-59 |
| NCAAB | 2021/02/13 21:00 | Illinois St v Southern Illinois | L | 80-55 |
| NCAAB | 2021/02/27 23:00 | Southern Illinois v Loyola Chicago | W | 58-65 |
| NCAAB | 2021/02/27 02:00 | Southern Illinois v Loyola Chicago | W | 52-60 |
| NCAAB | 2021/02/18 01:00 | Valparaiso v Loyola Chicago | W | 52-54 |
| NCAAB | 2021/02/14 20:00 | Loyola Chicago v Drake | L | 50-51 |
| NCAAB | 2021/02/13 17:00 | Loyola Chicago v Drake | W | 81-54 |
| NCAAB | 2021/02/07 19:00 | Evansville v Loyola Chicago | W | 58-69 |
| NCAAB | 2021/02/06 19:00 | Evansville v Loyola Chicago | W | 55-68 |
| NCAAB | 2021/02/02 01:00 | Loyola Chicago v Missouri State | W | 70-50 |