[10] NY Islanders 2-4 BUF Sabres [31] 2021-05-03 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | W | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-1 |
| NHL | 2019/12/14 18:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2019/11/02 23:00 | NY Islanders v BUF Sabres | W | 1-0 |
Home History
| NHL | 2021/05/01 23:00 | NY Rangers v NY Islanders | W | 0-3 |
| NHL | 2021/04/29 23:00 | NY Islanders v NY Rangers | W | 4-0 |
| NHL | 2021/04/27 23:00 | NY Islanders v WAS Capitals | L | 0-1 |
| NHL | 2021/04/24 23:00 | WAS Capitals v NY Islanders | L | 6-3 |
| NHL | 2021/04/22 23:00 | WAS Capitals v NY Islanders | L | 1-0 |
| NHL | 2021/04/20 23:00 | NY Rangers v NY Islanders | W | 1-6 |
| NHL | 2021/04/18 22:30 | NY Islanders v PHI Flyers | W | 1-0 |
| NHL | 2021/04/16 23:00 | NY Islanders v BOS Bruins | L | 0-3 |
Away History
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | L | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | L | 2-5 |
| NHL | 2021/04/27 23:00 | BUF Sabres v NY Rangers | L | 1-3 |
| NHL | 2021/04/25 22:00 | BUF Sabres v NY Rangers | L | 3-6 |
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | W | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | L | 2-0 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | W | 2-4 |