[27] John Isner 6-4,6-3 Salvatore Caruso [84] 2021-03-16 01:20
Stadium: Grandstand Round: 25 Ground: Hardcourt outdoor
Home History
| ATP Delray Beach | 2021/01/11 23:00 | Sebastian Korda v John Isner | 6-3,4-6,6-3 |
| ATP Delray Beach | 2021/01/10 01:35 | Thiago Monteiro v John Isner | 4-6,6-7 |
| French Open | 2020/09/30 09:30 | Sebastian Korda v John Isner | 6-4,6-4,2-6,6-4 |
| French Open | 2020/09/27 11:30 | Elliot Benchetrit v John Isner | 4-6,1-6,3-6 |
| US Open | 2020/08/31 22:30 | Steve Johnson v John Isner | 6-7,6-3,6-7,6-3,7-6 |
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP New York | 2020/08/24 17:05 | John Isner v John Millman | 4-6,7-6,7-6 |
| ATP New York | 2020/08/23 19:20 | John Isner v Hubert Hurkacz | 7-5,6-4 |
Away History
| ATP Santiago | 2021/03/08 19:35 | Roberto Carballes Baena v Salvatore Caruso | 6-4,7-6 |
| ATP Buenos Aires | 2021/03/02 14:30 | Gianluca Mager v Salvatore Caruso | 7-6,6-4 |
| Australian Open | 2021/02/11 05:55 | Fabio Fognini v Salvatore Caruso | 4-6,6-2,2-6,6-3,7-6 |
| Australian Open | 2021/02/09 04:20 | Henri Laaksonen v Salvatore Caruso | 2-6,4-6,3-6 |
| ATP Great Ocean Road Open | 2021/02/04 23:30 | Miomir Kecmanovic v Salvatore Caruso | 7-6,5-7,7-5 |
| ATP Great Ocean Road Open | 2021/02/03 01:40 | Salvatore Caruso v Tennys Sandgren | 6-4,6-7,6-1 |
| ATP Great Ocean Road Open | 2021/02/01 08:55 | Andreas Seppi v Salvatore Caruso | 5-7,6-7 |
| ATP Antalya | 2021/01/07 11:00 | Salvatore Caruso v Alexander Bublik | 3-6,3-6 |