[120] Lorenzo Musetti 2-6,6-3,7-6 Frances Tiafoe [56] 2021-03-18 00:00
Stadium: Cancha 3 Round: 26 Ground: Hardcourt outdoor
Head to Head
| Challenger Parma | 2020/10/07 15:10 | Frances Tiafoe v Lorenzo Musetti | 6-3,3-6,6-3 |
| Challenger Forli | 2020/09/23 10:00 | Frances Tiafoe v Lorenzo Musetti | 4-6,7-5,2-6 |
Home History
| ATP Acapulco | 2021/03/17 00:00 | Diego Schwartzman v Lorenzo Musetti | 3-6,6-2,4-6 |
| ATP Acapulco | 2021/03/16 00:00 | Lorenzo Musetti v Frederico Ferreira Silva | 6-4,6-2 |
| ATP Acapulco | 2021/03/15 00:55 | Lorenzo Musetti v Agustin Velotti | 6-3,7-5 |
| ATP Acapulco | 2021/03/14 01:30 | Lorenzo Musetti v Juan A H Serrano | 3-6,6-1,6-0 |
| Challenger Gran Canaria | 2021/02/25 11:00 | Lorenzo Musetti v Alex Molcan | 6-7,6-7 |
| Challenger Gran Canaria | 2021/02/24 10:00 | Lorenzo Musetti v Alex M Pujolras | 6-3,7-5 |
| Challenger Biella | 2021/02/21 14:30 | Soonwoo Kwon v Lorenzo Musetti | 6-2,6-3 |
| Challenger Biella | 2021/02/20 12:15 | Andreas Seppi v Lorenzo Musetti | 6-3,3-6,4-6 |
Away History
| ATP Acapulco | 2021/03/17 00:00 | Brandon Nakashima v Frances Tiafoe | 4-6,7-6,6-7 |
| ATP Santiago | 2021/03/10 16:40 | Frances Tiafoe v Facundo Bagnis | 6-7,6-7 |
| ATP Santiago | 2021/03/08 22:30 | Frances Tiafoe v Nicolas Jarry | 7-6,6-7,7-6 |
| ATP Buenos Aires | 2021/03/04 21:00 | Jaume Munar v Frances Tiafoe | 7-6,6-4 |
| ATP Buenos Aires | 2021/03/02 21:00 | Facundo Bagnis v Frances Tiafoe | 1-6,3-6 |
| Australian Open | 2021/02/10 03:30 | Novak Djokovic v Frances Tiafoe | 6-3,6-7,7-6,6-3 |
| Australian Open | 2021/02/08 06:00 | Frances Tiafoe v Stefano Travaglia | 7-6,6-2,6-2 |
| ATP Murray River Open | 2021/02/01 00:00 | Frances Tiafoe v Corentin Moutet | 6-3,4-6,4-6 |