Santos 2-2 San Lorenzo 2021-04-14 00:30
Stadium: Urbano Caldeira Round: 16
Referee: Esteban Ostojich Home Manager: Ariel Holan Away Manager: Diego Dabove
Head to Head
| Copa Libertadores Qualification | 2021/04/07 00:30 | San Lorenzo v Santos | W | 1-3 |
Home History
| Brazil Campeonato Paulista | 2021/04/11 01:00 | Santos v Botafogo SP | D | 0-0 |
| Copa Libertadores Qualification | 2021/04/07 00:30 | San Lorenzo v Santos | W | 1-3 |
| Copa Libertadores Qualification | 2021/03/16 22:15 | CD Lara v Santos | D | 1-1 |
| Brazil Campeonato Paulista | 2021/03/13 22:00 | Santos v Ituano | W | 2-1 |
| Copa Libertadores Qualification | 2021/03/09 22:15 | Santos v CD Lara | W | 2-1 |
| Brazil Campeonato Paulista | 2021/03/06 22:00 | Sao Paulo v Santos | L | 4-0 |
| Brazil Campeonato Paulista | 2021/03/03 20:00 | Santos v Ferroviaria SP | D | 1-1 |
| Brazil Campeonato Paulista | 2021/02/28 22:00 | Santo Andre SP v Santos | D | 2-2 |
Away History
| Argentina Copa de la Liga Profesional | 2021/04/10 00:00 | Platense v San Lorenzo | W | 2-4 |
| Copa Libertadores Qualification | 2021/04/07 00:30 | San Lorenzo v Santos | L | 1-3 |
| Argentina Copa de la Liga Profesional | 2021/04/02 22:00 | San Lorenzo v Rosario Central | W | 2-0 |
| Argentina Copa de la Liga Profesional | 2021/03/29 22:00 | Estudiantes LP v San Lorenzo | W | 0-2 |
| Argentina Cup | 2021/03/25 22:10 | San Lorenzo v Defensa y Justicia | L | 0-2 |
| Argentina Copa de la Liga Profesional | 2021/03/21 21:30 | San Lorenzo v CA Aldosivi | L | 1-2 |
| Copa Libertadores Qualification | 2021/03/18 00:30 | San Lorenzo v Universidad de Chile | W | 2-0 |
| Argentina Copa de la Liga Profesional | 2021/03/15 00:30 | Banfield v San Lorenzo | D | 0-0 |