[39] Kei Nishikori 3-6,6-3,1-6 Stefanos Tsitsipas [5] 2021-03-29 23:00
Stadium: Grandstand Round: 25 Ground: Hardcourt outdoor
Home History
| ATP Miami | 2021/03/27 15:00 | Kei Nishikori v Aljaz Bedene | 7-6,5-7,6-4 |
| ATP Dubai | 2021/03/18 15:35 | Lloyd Harris v Kei Nishikori | 6-1,3-6,6-3 |
| ATP Dubai | 2021/03/17 15:00 | Aljaz Bedene v Kei Nishikori | 4-6,4-6 |
| ATP Dubai | 2021/03/16 15:00 | Kei Nishikori v David Goffin | 6-3,7-6 |
| ATP Dubai | 2021/03/14 10:00 | Kei Nishikori v Reilly Opelka | 3-6,6-3,6-4 |
| ATP Marseille | 2021/03/09 15:15 | Kei Nishikori v Pierre-Hugues Herbert | 1-6,4-6 |
| ATP Rotterdam | 2021/03/05 19:30 | Borna Coric v Kei Nishikori | 7-6,7-6 |
| ATP Rotterdam | 2021/03/03 13:35 | Alex De Minaur v Kei Nishikori | 3-6,6-2,5-7 |
Away History
| ATP Miami | 2021/03/27 16:25 | Damir Dzumhur v Stefanos Tsitsipas | 1-6,4-6 |
| ATP Acapulco | 2021/03/21 03:00 | Stefanos Tsitsipas v Alexander Zverev | 4-6,6-7 |
| ATP Acapulco | 2021/03/20 04:25 | Stefanos Tsitsipas v Lorenzo Musetti | 6-1,6-3 |
| ATP Acapulco | 2021/03/19 02:10 | Stefanos Tsitsipas v Felix Auger Aliassime | 7-5,4-6,6-3 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP Acapulco | 2021/03/17 02:40 | Stefanos Tsitsipas v Benoit Paire | 6-3,6-1 |
| ATP Marseille | 2021/03/12 17:00 | Pierre-Hugues Herbert v Stefanos Tsitsipas | 6-7,6-4,6-2 |
| ATP Marseille | 2021/03/11 17:55 | Lucas Pouille v Stefanos Tsitsipas | 2-6,3-6 |