Jacksonville State 44-23 Eastern Illinois 2021-04-03 18:00
Stadium: O'Brien Stadium Round: 1
Head to Head
| NCAAF | 2019/10/12 17:00 | Jacksonville State v Eastern Illinois | W | 28-20 |
| NCAAF | 2018/10/13 20:00 | Eastern Illinois v Jacksonville State | W | 22-49 |
| NCAAF | 2017/10/21 19:00 | Eastern Illinois v Jacksonville State | W | 14-30 |
Home History
| NCAAF | 2021/03/28 19:00 | Austin Peay v Jacksonville State | L | 13-10 |
| NCAAF | 2021/03/21 19:00 | SE Missouri St v Jacksonville State | W | 3-21 |
| NCAAF | 2021/03/14 18:00 | Jacksonville State v Tennessee Martin | W | 37-20 |
| NCAAF | 2021/03/07 20:00 | Jacksonville State v Tennessee State | W | 38-16 |
| NCAAF | 2021/02/28 21:00 | Tennessee Tech v Jacksonville State | W | 10-27 |
| NCAAF | 2020/10/23 23:00 | Jacksonville State v Florida Intl | W | 19-10 |
| NCAAF | 2020/10/17 18:00 | Jacksonville State v North Alabama | W | 24-17 |
| NCAAF | 2020/10/10 19:00 | Mercer v Jacksonville State | W | 28-34 |
Away History
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
| NCAAF | 2021/03/14 18:00 | Eastern Illinois v Tennessee State | L | 20-21 |
| NCAAF | 2021/03/07 19:00 | Eastern Illinois v Tennessee Martin | L | 15-28 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | L | 7-47 |
| NCAAF | 2019/11/23 20:00 | Eastern Illinois v Austin Peay | L | 7-35 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | L | 26-12 |
| NCAAF | 2019/11/09 20:00 | Eastern Illinois v Tennessee State | W | 49-38 |