[1] Royal Pari FC 3-2 Real Santa Cruz [15] 2021-04-09 19:00
Stadium: Estadio Ramon Tahuichi Aguilera Round: 4
Head to Head
| Bolivia Apertura | 2020/12/24 19:00 | Real Santa Cruz v Royal Pari FC | W | 2-4 |
| Bolivia Apertura | 2020/03/03 00:30 | Royal Pari FC v Real Santa Cruz | L | 0-2 |
Home History
| Bolivia Apertura | 2021/04/03 00:00 | San Jose v Royal Pari FC | W | 0-3 |
| Bolivia Apertura | 2021/03/15 19:00 | Royal Pari FC v Real Tomayapo | W | 4-2 |
| Bolivia Clausura | 2021/03/11 19:00 | Club Aurora v Royal Pari FC | W | 0-8 |
| Copa Libertadores Qualification | 2021/03/04 00:30 | Guarani Asuncion v Royal Pari FC | D | 1-1 |
| Copa Libertadores Qualification | 2021/02/25 00:30 | Royal Pari FC v Guarani Asuncion | L | 1-4 |
| Bolivia Apertura | 2020/12/31 19:00 | Royal Pari FC v Jorge Wilstermann | W | 3-0 |
| Bolivia Apertura | 2020/12/29 19:00 | Always Ready v Royal Pari FC | L | 2-1 |
| Bolivia Apertura | 2020/12/27 19:00 | Royal Pari FC v Real Potosi | D | 1-1 |
Away History
| Bolivia Apertura | 2021/04/03 19:00 | Real Santa Cruz v Always Ready | L | 2-3 |
| Bolivia Apertura | 2021/03/28 19:00 | Real Santa Cruz v Jorge Wilstermann | L | 0-2 |
| Bolivia Apertura | 2021/03/13 23:30 | Atletico Palmaflor Vinto v Real Santa Cruz | L | 1-0 |
| Bolivia Apertura | 2020/12/31 19:00 | Club Aurora v Real Santa Cruz | D | 1-1 |
| Bolivia Apertura | 2020/12/29 19:00 | Real Santa Cruz v Guabira | D | 4-4 |
| Bolivia Apertura | 2020/12/27 19:00 | Nacional Potosi v Real Santa Cruz | L | 1-0 |
| Bolivia Apertura | 2020/12/24 19:00 | Real Santa Cruz v Royal Pari FC | L | 2-4 |
| Bolivia Apertura | 2020/12/22 21:00 | Bolivar v Real Santa Cruz | L | 4-0 |