[7] Guarani Asuncion 2-0 River Plate Asuncion [10] 2021-04-12 23:00
Stadium: Estadio Rogelio Silvino Livieres Round: 11
Referee: Juan Gabriel Benitez Home Manager: Gustavo Costas Away Manager: Ariel Galeano
Head to Head
| Paraguay Division Profesional | 2021/02/09 21:30 | River Plate Asuncion v Guarani Asuncion | W | 1-4 |
| Paraguay Division Profesional | 2020/11/01 21:15 | River Plate Asuncion v Guarani Asuncion | L | 1-0 |
| Paraguay Division Profesional | 2020/08/29 20:30 | River Plate Asuncion v Guarani Asuncion | L | 1-0 |
| Paraguay Division Profesional | 2020/08/05 22:30 | Guarani Asuncion v River Plate Asuncion | W | 3-0 |
| Paraguay Division Profesional | 2019/09/28 22:00 | River Plate Asuncion v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2019/07/12 23:30 | Guarani Asuncion v River Plate Asuncion | L | 1-3 |
| Paraguay Division Profesional | 2019/05/06 23:30 | River Plate Asuncion v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2019/03/04 21:45 | Guarani Asuncion v River Plate Asuncion | W | 2-1 |
Home History
| Paraguay Division Profesional | 2021/04/02 00:30 | Nacional Asuncion v Guarani Asuncion | L | 2-0 |
| Paraguay Division Profesional | 2021/03/28 23:00 | Libertad Asuncion v Guarani Asuncion | D | 1-1 |
| Paraguay Division Profesional | 2021/03/21 21:15 | Cerro Porteno v Guarani Asuncion | L | 2-1 |
| Copa Libertadores Qualification | 2021/03/19 00:30 | Atletico Nacional Medellin v Guarani Asuncion | L | 3-0 |
| Paraguay Division Profesional | 2021/03/14 20:45 | Guarani Asuncion v Guairena FC | L | 0-3 |
| Copa Libertadores Qualification | 2021/03/12 00:30 | Guarani Asuncion v Atletico Nacional Medellin | L | 0-2 |
| Paraguay Division Profesional | 2021/03/07 22:30 | Guarani Asuncion v Sportivo Luqueno | L | 0-1 |
| Copa Libertadores Qualification | 2021/03/04 00:30 | Guarani Asuncion v Royal Pari FC | D | 1-1 |
Away History
| Copa Sudamericana | 2021/04/08 22:15 | River Plate Asuncion v Guairena FC | W | 4-2 |
| Paraguay Division Profesional | 2021/04/01 22:15 | River Plate Asuncion v 12 de Octubre | L | 0-2 |
| Paraguay Division Profesional | 2021/03/21 23:30 | Olimpia Asuncion v River Plate Asuncion | L | 5-1 |
| Copa Sudamericana | 2021/03/18 22:15 | Guairena FC v River Plate Asuncion | W | 1-2 |
| Paraguay Division Profesional | 2021/03/13 21:30 | River Plate Asuncion v Nacional Asuncion | D | 0-0 |
| Paraguay Division Profesional | 2021/03/09 23:45 | Cerro Porteno v River Plate Asuncion | L | 3-0 |
| Paraguay Division Profesional | 2021/03/05 21:15 | River Plate Asuncion v Guairena FC | L | 0-1 |
| Paraguay Division Profesional | 2021/03/01 23:45 | Libertad Asuncion v River Plate Asuncion | L | 2-1 |