[3] Louisville City FC 2-1 San Diego Loyal [7] 2021-05-22 23:30
Stadium: Lynn Family Stadium Round: 1
Home History
| USA USL Championship | 2021/05/08 23:30 | Louisville City FC v Birmingham Legion FC | D | 1-1 |
| USA USL Championship | 2021/04/24 23:30 | Louisville City FC v Atlanta United II | W | 2-0 |
| America Friendlies | 2021/04/03 18:00 | Chattanooga FC v Louisville City FC | W | 2-3 |
| USA USL Championship | 2020/10/24 23:30 | Louisville City FC v Tampa Bay Rowdies | L | 1-2 |
| USA USL Championship | 2020/10/17 23:30 | Louisville City FC v Saint Louis FC | W | 2-0 |
| USA USL Championship | 2020/10/10 23:30 | Louisville City FC v Pittsburgh Riverhounds | W | 2-0 |
| USA USL Championship | 2020/10/03 23:30 | Louisville City FC v Sporting Kansas City II | W | 2-1 |
| USA USL Championship | 2020/09/27 00:00 | Saint Louis FC v Louisville City FC | W | 0-1 |
Away History
| USA USL Championship | 2021/05/14 02:00 | Tacoma Defiance v San Diego Loyal | L | 3-1 |
| USA USL Championship | 2021/05/07 00:00 | Rio Grande Valley FC Toros v San Diego Loyal | L | 1-0 |
| USA USL Championship | 2021/05/01 02:00 | Phoenix Rising FC v San Diego Loyal | L | 4-1 |
| USA USL Championship | 2020/10/01 02:00 | San Diego Loyal v Phoenix Rising FC | L | 0-3 |
| USA USL Championship | 2020/09/24 02:00 | Ventura County FC v San Diego Loyal | D | 1-1 |
| USA USL Championship | 2020/09/20 02:30 | Phoenix Rising FC v San Diego Loyal | W | 2-3 |
| USA USL Championship | 2020/09/14 02:00 | San Diego Loyal v Orange County SC | W | 2-0 |
| USA USL Championship | 2020/09/10 02:00 | Ventura County FC v San Diego Loyal | W | 0-3 |