SE Louisiana 48-55 Southern Illinois 2021-04-17 17:00
Stadium: Saluki Stadium Round: 1
Home History
| NCAAF | 2021/04/10 20:00 | SE Louisiana v Nicholls State | W | 52-45 |
| NCAAF | 2021/04/03 23:00 | Lamar v SE Louisiana | W | 12-42 |
| NCAAF | 2021/03/20 19:00 | SE Louisiana v Incarnate Word | L | 45-56 |
| NCAAF | 2021/03/14 00:00 | Northwestern State v SE Louisiana | W | 24-27 |
| NCAAF | 2021/03/07 00:00 | McNeese State v SE Louisiana | W | 20-25 |
| NCAAF | 2021/02/28 00:00 | SE Louisiana v Sam Houston State | L | 38-43 |
| NCAAF | 2019/12/07 20:00 | SE Louisiana v Montana | L | 28-73 |
| NCAAF | 2019/11/30 21:00 | Villanova v SE Louisiana | W | 44-45 |
Away History
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | W | 16-17 |
| NCAAF | 2021/03/06 17:00 | SO Illinois v Youngstown State | W | 30-22 |
| NCAAF | 2021/02/27 18:00 | North Dakota State v SO Illinois | W | 14-38 |
| NCAAF | 2021/02/20 18:00 | SO Illinois v North Dakota | L | 21-44 |
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | W | 17-20 |
| NCAAF | 2019/11/23 20:00 | North Dakota State v SO Illinois | L | 21-7 |