[1] Fluminense 2-1 Independiente Santa Fe [4] 2021-05-13 00:00
Stadium: Maracana Round: 4
Referee: Eber Aquino Home Manager: Roger Machado Away Manager: Harold Rivera Roa
Head to Head
| Copa Libertadores | 2021/04/29 00:00 | Independiente Santa Fe v Fluminense | W | 1-2 |
Home History
| Brazil Campeonato Carioca | 2021/05/09 19:00 | Fluminense v Portuguesa RJ | W | 3-1 |
| Copa Libertadores | 2021/05/07 00:00 | Junior v Fluminense | D | 1-1 |
| Brazil Campeonato Carioca | 2021/05/02 19:00 | Portuguesa RJ v Fluminense | D | 1-1 |
| Copa Libertadores | 2021/04/29 00:00 | Independiente Santa Fe v Fluminense | W | 1-2 |
| Brazil Campeonato Carioca | 2021/04/25 14:05 | Fluminense v Madureira RJ | W | 4-1 |
| Copa Libertadores | 2021/04/22 22:00 | Fluminense v River Plate | D | 1-1 |
| Brazil Campeonato Carioca | 2021/04/17 19:00 | Fluminense v Botafogo | W | 1-0 |
| Brazil Campeonato Carioca | 2021/04/11 21:00 | Fluminense v Nova Iguacu | W | 3-1 |
Away History
| Copa Libertadores | 2021/05/07 00:00 | Independiente Santa Fe v River Plate | D | 0-0 |
| Colombia Primera A | 2021/05/02 18:00 | Independiente Santa Fe v Junior | D | 0-0 |
| Copa Libertadores | 2021/04/29 00:00 | Independiente Santa Fe v Fluminense | L | 1-2 |
| Colombia Primera A | 2021/04/25 20:30 | Junior v Independiente Santa Fe | L | 3-1 |
| Copa Libertadores | 2021/04/23 02:00 | Junior v Independiente Santa Fe | D | 1-1 |
| Colombia Primera A | 2021/04/18 20:30 | La Equidad v Independiente Santa Fe | W | 1-2 |
| Colombia Primera A | 2021/04/12 01:00 | Independiente Santa Fe v Millonarios | L | 1-2 |
| Colombia Primera A | 2021/04/07 01:00 | Alianza Petrolera v Independiente Santa Fe | W | 0-3 |