[7] East Carolina 19-33 Appalachian State [7] 2021-09-02 23:30
Stadium: Bank of America Stadium Round: 1
Home Manager: Shawn Clark Away Manager: Mike Houston
Head to Head
| NCAAF | 2012/09/01 12:00 | East Carolina v Appalachian St | W | 35-13 |
| NCAAF | 2009/09/05 12:00 | East Carolina v Appalachian St | W | 29-24 |
Home History
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |
| NCAAF | 2020/11/21 17:00 | East Carolina v Temple | W | 28-3 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
| NCAAF | 2020/11/07 17:00 | Tulane v East Carolina | L | 38-21 |
| NCAAF | 2020/10/31 01:00 | East Carolina v Tulsa | L | 30-34 |
| NCAAF | 2020/10/17 16:00 | Navy v East Carolina | L | 27-23 |
| NCAAF | 2020/10/10 23:00 | East Carolina v South Florida | W | 44-24 |
| NCAAF | 2020/10/03 16:00 | East Carolina v Georgia State | L | 29-49 |
Away History
| NCAAF | 2020/12/21 19:30 | North Texas v Appalachian St | W | 28-56 |
| NCAAF | 2020/12/12 23:00 | Appalachian St v Georgia Southern | W | 34-26 |
| NCAAF | 2020/12/05 01:30 | Lafayette v Appalachian St | L | 24-21 |
| NCAAF | 2020/11/28 20:30 | Troy v Appalachian St | W | 10-47 |
| NCAAF | 2020/11/21 17:00 | Appalachian St v Coastal Carolina | L | 23-34 |
| NCAAF | 2020/11/14 19:30 | Georgia State v Appalachian St | W | 13-17 |
| NCAAF | 2020/11/07 20:00 | Appalachian St v Texas State | W | 38-17 |
| NCAAF | 2020/10/31 20:00 | Appalachian St v UL Monroe | W | 31-13 |