[81] Louisville 24-43 Mississippi [81] 2021-09-07 00:00
Stadium: Mercedes-Benz Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Lane Kiffin
Home History
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |
| NCAAF | 2020/10/17 18:30 | Louisville v Notre Dame | L | 7-12 |
| NCAAF | 2020/10/09 23:00 | Louisville v Georgia Tech | L | 27-46 |
Away History
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | W | 26-20 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | L | 48-53 |
| NCAAF | 2020/11/28 21:00 | Mississippi State v Mississippi | W | 24-31 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | W | 42-59 |
| NCAAF | 2020/10/31 20:00 | Mississippi v Vanderbilt | W | 54-21 |
| NCAAF | 2020/10/24 16:00 | Auburn v Mississippi | L | 35-28 |
| NCAAF | 2020/10/17 19:30 | Mississippi v Arkansas | L | 21-33 |
| NCAAF | 2020/10/10 23:30 | Alabama v Mississippi | L | 63-48 |