Eastern Illinois 0-46 South Carolina 2021-09-04 23:00
Stadium: Williams-Brice Stadium Round: 1
Home History
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
| NCAAF | 2021/03/14 18:00 | Eastern Illinois v Tennessee State | L | 20-21 |
| NCAAF | 2021/03/07 19:00 | Eastern Illinois v Tennessee Martin | L | 15-28 |
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | L | 7-47 |
| NCAAF | 2019/11/23 20:00 | Eastern Illinois v Austin Peay | L | 7-35 |
Away History
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | L | 18-41 |
| NCAAF | 2020/11/29 00:30 | Georgia v South Carolina | L | 45-16 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | L | 17-10 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | L | 42-59 |
| NCAAF | 2020/11/08 00:00 | Texas A&M v South Carolina | L | 48-3 |
| NCAAF | 2020/10/24 23:00 | South Carolina v LSU | L | 24-52 |
| NCAAF | 2020/10/17 16:00 | Auburn v South Carolina | W | 22-30 |
| NCAAF | 2020/10/10 16:00 | South Carolina v Vanderbilt | W | 41-7 |