[6] Guabira 1-0 Real Santa Cruz [15] 2021-05-01 23:30
Stadium: Estadio Ramon Tahuichi Aguilera Round: 6
Head to Head
| Bolivia Apertura | 2020/12/29 19:00 | Real Santa Cruz v Guabira | D | 4-4 |
| Bolivia Apertura | 2020/03/15 21:15 | Guabira v Real Santa Cruz | W | 1-0 |
Home History
| Copa Sudamericana | 2021/04/27 22:15 | EC Bahia v Guabira | L | 5-0 |
| Bolivia Apertura | 2021/04/24 22:15 | San Jose v Guabira | W | 0-1 |
| Copa Sudamericana | 2021/04/22 00:30 | Guabira v CA Independiente | L | 1-3 |
| Bolivia Apertura | 2021/04/11 19:00 | Guabira v Real Tomayapo | L | 0-2 |
| Copa Sudamericana | 2021/04/07 22:15 | Nacional Potosi v Guabira | W | 1-2 |
| Bolivia Apertura | 2021/04/02 19:00 | Club Aurora v Guabira | L | 2-1 |
| Bolivia Apertura | 2021/03/21 21:15 | Blooming v Guabira | W | 0-1 |
| Copa Sudamericana | 2021/03/17 22:15 | Guabira v Nacional Potosi | W | 4-1 |
Away History
| Bolivia Apertura | 2021/04/09 19:00 | Royal Pari FC v Real Santa Cruz | L | 3-2 |
| Bolivia Apertura | 2021/04/03 19:00 | Real Santa Cruz v Always Ready | L | 2-3 |
| Bolivia Apertura | 2021/03/28 19:00 | Real Santa Cruz v Jorge Wilstermann | L | 0-2 |
| Bolivia Apertura | 2021/03/13 23:30 | Atletico Palmaflor Vinto v Real Santa Cruz | L | 1-0 |
| Bolivia Apertura | 2020/12/31 19:00 | Club Aurora v Real Santa Cruz | D | 1-1 |
| Bolivia Apertura | 2020/12/29 19:00 | Real Santa Cruz v Guabira | D | 4-4 |
| Bolivia Apertura | 2020/12/27 19:00 | Nacional Potosi v Real Santa Cruz | L | 1-0 |
| Bolivia Apertura | 2020/12/24 19:00 | Real Santa Cruz v Royal Pari FC | L | 2-4 |