[20] Karolina Muchova 6-4,3-6,6-1 Naomi Osaka [2] 2021-05-02 09:00
Stadium: Manolo Santana Stadium Round: 25 Ground: Clay
Head to Head
| WTA New York | 2020/08/24 19:50 | Naomi Osaka v Karolina Muchova | 6-7,6-4,6-2 |
Home History
| WTA Madrid | 2021/04/30 09:00 | Qiang Wang v Karolina Muchova | 1-6,3-6 |
| WTA Stuttgart | 2021/04/20 09:30 | Ekaterina Alexandrova v Karolina Muchova | 4-6,6-2,6-3 |
| Australian Open Women | 2021/02/18 04:40 | Karolina Muchova v Jennifer Brady | 4-6,6-3,4-6 |
| Australian Open Women | 2021/02/17 00:00 | Ashleigh Barty v Karolina Muchova | 6-1,3-6,2-6 |
| Australian Open Women | 2021/02/15 07:00 | Elise Mertens v Karolina Muchova | 6-7,5-7 |
| Australian Open Women | 2021/02/13 00:00 | Karolina Muchova v Karolina Pliskova | 7-5,7-5 |
| Australian Open Women | 2021/02/11 00:00 | Karolina Muchova v Mona Barthel | 6-4,6-1 |
| Australian Open Women | 2021/02/09 05:55 | Karolina Muchova v Jelena Ostapenko | 7-5,6-2 |
Away History
| WTA Madrid | 2021/04/30 10:20 | Misaki Doi v Naomi Osaka | 5-7,2-6 |
| WTA Miami | 2021/03/31 17:00 | Maria Sakkari v Naomi Osaka | 6-0,6-4 |
| WTA Miami | 2021/03/29 19:00 | Elise Mertens v Naomi Osaka | 3-6,3-6 |
| WTA Miami | 2021/03/26 17:00 | Ajla Tomljanovic v Naomi Osaka | 6-7,4-6 |
| Australian Open Women | 2021/02/20 08:30 | Jennifer Brady v Naomi Osaka | 4-6,3-6 |
| Australian Open Women | 2021/02/18 03:00 | Naomi Osaka v Serena Williams | 6-3,6-4 |
| Australian Open Women | 2021/02/16 01:30 | Su-Wei Hsieh v Naomi Osaka | 2-6,2-6 |
| Australian Open Women | 2021/02/14 00:00 | Garbine Muguruza v Naomi Osaka | 6-4,4-6,5-7 |