[23] Karen Khachanov 7-6,2-6,2-6 Kei Nishikori [43] 2021-05-04 09:00
Stadium: Manolo Santana Stadium Round: 24 Ground: Clay
Head to Head
| ATP Vienna | 2018/10/25 11:00 | Karen Khachanov v Kei Nishikori | 2-6,2-6 |
| ATP Halle | 2018/06/20 11:50 | Kei Nishikori v Karen Khachanov | 2-6,2-6 |
| US Open 2016 | 2016/09/01 16:20 | Kei Nishikori v Karen Khachanov | 6-4,4-6,6-4,6-3 |
Home History
| ATP Barcelona | 2021/04/20 17:40 | Karen Khachanov v Cameron Norrie | 4-6,6-3,3-6 |
| ATP Monte Carlo | 2021/04/14 13:20 | Karen Khachanov v Pablo Carreno Busta | 2-6,3-6 |
| ATP Monte Carlo | 2021/04/13 13:45 | Karen Khachanov v Laslo Djere | 6-4,6-1 |
| ATP Miami | 2021/03/28 17:10 | Jannik Sinner v Karen Khachanov | 4-6,7-6,6-4 |
| ATP Miami | 2021/03/26 19:10 | Yannick Hanfmann v Karen Khachanov | 3-6,2-6 |
| ATP Dubai | 2021/03/17 10:00 | Jeremy Chardy v Karen Khachanov | 6-7,6-4,6-4 |
| ATP Dubai | 2021/03/16 10:25 | Alexei Popyrin v Karen Khachanov | 4-6,6-3,6-7 |
| ATP Marseille | 2021/03/12 13:30 | Karen Khachanov v Matthew Ebden | 6-4,4-6,2-6 |
Away History
| ATP Barcelona | 2021/04/22 14:00 | Rafael Nadal v Kei Nishikori | 6-0,2-6,6-2 |
| ATP Barcelona | 2021/04/21 15:00 | Kei Nishikori v Cristian Garin | 7-6,4-6,6-1 |
| ATP Barcelona | 2021/04/19 13:10 | Kei Nishikori v Guido Pella | 4-6,7-6,6-2 |
| ATP Miami | 2021/03/29 23:00 | Kei Nishikori v Stefanos Tsitsipas | 3-6,6-3,1-6 |
| ATP Miami | 2021/03/27 15:00 | Kei Nishikori v Aljaz Bedene | 7-6,5-7,6-4 |
| ATP Dubai | 2021/03/18 15:35 | Lloyd Harris v Kei Nishikori | 6-1,3-6,6-3 |
| ATP Dubai | 2021/03/17 15:00 | Aljaz Bedene v Kei Nishikori | 4-6,4-6 |
| ATP Dubai | 2021/03/16 15:00 | Kei Nishikori v David Goffin | 6-3,7-6 |