[11] Roberto Bautista-Agut 4-6,7-6,6-7 John Isner [39] 2021-05-05 16:00
Stadium: Arantxa Sanchez Stadium Round: 25 Ground: Clay
Head to Head
| ATP Miami | 2021/03/30 15:00 | John Isner v Roberto Bautista-Agut | 3-6,6-4,6-7 |
| ATP Miami | 2019/03/27 20:20 | Roberto Bautista-Agut v John Isner | 6-7,6-7 |
Home History
| ATP Madrid | 2021/05/04 14:30 | Roberto Bautista-Agut v Marco Cecchinato | 6-2,6-7,7-5 |
| ATP Barcelona | 2021/04/22 10:40 | Roberto Bautista-Agut v Jannik Sinner | 6-7,2-6 |
| ATP Barcelona | 2021/04/20 16:00 | Roberto Bautista-Agut v Pablo Andujar | 6-4,6-0 |
| ATP Monte Carlo | 2021/04/15 14:50 | Andrey Rublev v Roberto Bautista-Agut | 7-6,5-7,6-3 |
| ATP Monte Carlo | 2021/04/14 12:15 | Tommy Paul v Roberto Bautista-Agut | 3-6,4-6 |
| ATP Monte Carlo | 2021/04/13 12:10 | Taylor Fritz v Roberto Bautista-Agut | 2-6,5-7 |
| ATP Miami | 2021/04/02 17:00 | Roberto Bautista-Agut v Jannik Sinner | 7-5,4-6,4-6 |
| ATP Miami | 2021/04/01 02:10 | Daniil Medvedev v Roberto Bautista-Agut | 4-6,2-6 |
Away History
| ATP Madrid | 2021/05/03 09:00 | John Isner v Miomir Kecmanovic | 6-4,7-6 |
| ATP Miami | 2021/03/30 15:00 | John Isner v Roberto Bautista-Agut | 3-6,6-4,6-7 |
| ATP Miami | 2021/03/28 15:00 | Felix Auger Aliassime v John Isner | 6-7,6-7 |
| ATP Miami | 2021/03/27 01:05 | Mackenzie McDonald v John Isner | 6-2,3-6,5-7 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP Acapulco | 2021/03/16 01:20 | John Isner v Salvatore Caruso | 6-4,6-3 |
| ATP Delray Beach | 2021/01/11 23:00 | Sebastian Korda v John Isner | 6-3,4-6,6-3 |
| ATP Delray Beach | 2021/01/10 01:35 | Thiago Monteiro v John Isner | 4-6,6-7 |