Head to Head
| Chile Primera B | 2019/04/28 20:00 | Melipilla v La Serena | L | 4-0 |
| World Club Friendlies | 2019/02/05 20:47 | La Serena v Melipilla | D | 0-0 |
| Chile Primera B | 2018/07/29 19:30 | La Serena v Melipilla | D | 2-2 |
| Chile Primera B | 2018/03/09 21:30 | Melipilla v La Serena | L | 2-0 |
Home History
| Chile Primera Division | 2021/05/22 15:00 | Cobresal v La Serena | L | 2-0 |
| Chile Primera Division | 2021/05/08 19:30 | La Serena v Nublense | W | 1-0 |
| Chile Primera Division | 2021/05/01 00:00 | Everton de Vina v La Serena | W | 0-4 |
| Chile Primera Division | 2021/04/24 19:30 | La Serena v Union Espanola | D | 0-0 |
| Chile Primera Division | 2021/04/17 22:00 | O'Higgins v La Serena | D | 0-0 |
| Chile Primera Division | 2021/04/11 19:00 | La Serena v Universidad de Chile | D | 0-0 |
| Chile Primera Division | 2021/04/04 21:00 | La Serena v Curico Unido | W | 2-0 |
| Chile Primera Division | 2021/03/30 23:00 | Audax Italiano v La Serena | L | 2-1 |
Away History
| Chile Primera Division | 2021/05/23 16:30 | Melipilla v CD Antofagasta | D | 1-1 |
| Chile Primera Division | 2021/05/08 22:00 | Santiago Wanderers v Melipilla | W | 0-3 |
| Chile Primera Division | 2021/05/02 22:00 | Melipilla v Universidad Catolica | W | 2-0 |
| Chile Primera Division | 2021/04/27 00:30 | Audax Italiano v Melipilla | L | 1-0 |
| Chile Primera Division | 2021/04/16 19:30 | Melipilla v Palestino | L | 0-1 |
| Chile Primera Division | 2021/04/10 20:00 | Union Espanola v Melipilla | W | 0-2 |
| Chile Primera Division | 2021/04/03 14:00 | Melipilla v Nublense | D | 1-1 |
| Chile Primera Division | 2021/03/27 14:00 | Curico Unido v Melipilla | L | 2-0 |