[8] Union Espanola 0-1 Colo Colo [2] 2021-08-14 20:30
Stadium: Estadio Santa Laura Round: 16
Referee: Gustavo Ahumada Home Manager: Cesar Bravo Away Manager: Gustavo Quinteros
Head to Head
| Chile Primera Division | 2020/12/12 21:00 | Union Espanola v Colo Colo | L | 1-2 |
| Chile Primera Division | 2020/10/14 21:30 | Colo Colo v Union Espanola | W | 3-5 |
| Chile Primera Division | 2019/08/16 23:30 | Colo Colo v Union Espanola | L | 1-0 |
| World Club Friendlies | 2019/07/06 23:04 | Union Espanola v Colo Colo | W | 1-0 |
| Chile Primera Division | 2019/02/17 22:00 | Union Espanola v Colo Colo | L | 1-3 |
| World Club Friendlies | 2019/01/23 22:00 | Colo Colo v Union Espanola | W | 0-1 |
| Chile Primera Division | 2018/10/07 23:00 | Colo Colo v Union Espanola | D | 1-1 |
| Chile Primera Division | 2018/05/19 21:30 | Union Espanola v Colo Colo | W | 3-2 |
Home History
| Chile Cup | 2021/08/12 00:00 | Huachipato v Union Espanola | W | 0-1 |
| Chile Primera Division | 2021/08/07 21:30 | Union Espanola v Nublense | W | 3-2 |
| Chile Cup | 2021/08/05 00:00 | Union Espanola v Huachipato | D | 1-1 |
| Chile Primera Division | 2021/08/01 17:30 | Palestino v Union Espanola | L | 3-2 |
| Chile Primera Division | 2021/07/28 19:30 | Union Espanola v Huachipato | W | 3-1 |
| Chile Primera Division | 2021/07/24 00:30 | Everton de Vina v Union Espanola | L | 2-0 |
| Chile Cup | 2021/07/12 19:00 | Union Espanola v Magallanes | W | 1-0 |
| Chile Cup | 2021/07/09 16:00 | Magallanes v Union Espanola | W | 0-1 |
Away History
| Chile Primera Division | 2021/08/08 21:30 | Colo Colo v Curico Unido | W | 2-0 |
| Chile Primera Division | 2021/08/02 00:00 | Melipilla v Colo Colo | W | 2-4 |
| Chile Primera Division | 2021/07/29 19:00 | Santiago Wanderers v Colo Colo | W | 0-4 |
| Chile Primera Division | 2021/07/25 00:00 | Colo Colo v Audax Italiano | D | 1-1 |
| Chile Primera Division | 2021/07/17 20:00 | Universidad Catolica v Colo Colo | D | 0-0 |
| Chile Cup | 2021/07/12 00:30 | Colo Colo v Palestino | D | 1-1 |
| Chile Cup | 2021/07/08 19:00 | Palestino v Colo Colo | W | 2-3 |
| Chile Cup | 2021/07/05 00:00 | Colo Colo v La Serena | W | 4-0 |