[29] IND Colts 16-25 TEN Titans [12] 2021-09-26 17:00
Stadium: Nissan Stadium Round: 1
Home Manager: Mike Vrabel Away Manager: Frank Reich
Head to Head
| NFL | 2020/11/29 18:00 | TEN Titans v IND Colts | L | 45-26 |
| NFL | 2020/11/13 01:20 | IND Colts v TEN Titans | W | 34-17 |
| NFL | 2019/12/01 18:00 | TEN Titans v IND Colts | L | 31-17 |
| NFL | 2019/09/15 17:00 | IND Colts v TEN Titans | W | 19-17 |
| NFL | 2018/12/31 01:20 | IND Colts v TEN Titans | W | 33-17 |
| NFL | 2018/11/18 18:00 | TEN Titans v IND Colts | W | 10-38 |
| NFL | 2017/11/26 18:00 | TEN Titans v IND Colts | L | 20-16 |
| NFL | 2017/10/17 00:30 | IND Colts v TEN Titans | L | 22-36 |
Home History
| NFL | 2021/09/19 17:00 | LA Rams v IND Colts | L | 27-24 |
| NFL | 2021/09/12 17:00 | SEA Seahawks v IND Colts | L | 28-16 |
| NFL Preseason | 2021/08/27 23:00 | IND Colts v DET Lions | W | 27-17 |
| NFL Preseason | 2021/08/22 00:00 | IND Colts v MIN Vikings | W | 12-10 |
| NFL Preseason | 2021/08/15 17:00 | CAR Panthers v IND Colts | W | 18-21 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL | 2021/01/03 21:25 | JAX Jaguars v IND Colts | W | 14-28 |
| NFL | 2020/12/27 18:00 | IND Colts v PIT Steelers | L | 24-28 |
Away History
| NFL | 2021/09/19 20:25 | TEN Titans v SEA Seahawks | W | 33-30 |
| NFL | 2021/09/12 17:00 | ARZ Cardinals v TEN Titans | L | 38-13 |
| NFL Preseason | 2021/08/28 23:00 | CHI Bears v TEN Titans | L | 27-24 |
| NFL Preseason | 2021/08/21 23:30 | TEN Titans v TB Buccaneers | W | 34-3 |
| NFL Preseason | 2021/08/13 23:00 | TEN Titans v ATL Falcons | W | 23-3 |
| NFL | 2021/01/10 18:05 | BAL Ravens v TEN Titans | L | 20-13 |
| NFL | 2021/01/03 21:25 | TEN Titans v HOU Texans | W | 41-38 |
| NFL | 2020/12/28 01:20 | TEN Titans v GB Packers | L | 14-40 |