Head to Head
| NFL Preseason | 2018/08/25 20:30 | SF 49ers v IND Colts | W | 17-23 |
| NFL | 2017/10/08 17:00 | SF 49ers v IND Colts | W | 23-26 |
Home History
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | W | 3-31 |
| NFL | 2021/10/12 00:15 | IND Colts v BAL Ravens | L | 25-31 |
| NFL | 2021/10/03 17:00 | IND Colts v MIA Dolphins | W | 27-17 |
| NFL | 2021/09/26 17:00 | IND Colts v TEN Titans | L | 16-25 |
| NFL | 2021/09/19 17:00 | LA Rams v IND Colts | L | 27-24 |
| NFL | 2021/09/12 17:00 | SEA Seahawks v IND Colts | L | 28-16 |
| NFL Preseason | 2021/08/27 23:00 | IND Colts v DET Lions | W | 27-17 |
| NFL Preseason | 2021/08/22 00:00 | IND Colts v MIN Vikings | W | 12-10 |
Away History
| NFL | 2021/10/10 20:25 | SF 49ers v ARZ Cardinals | L | 10-17 |
| NFL | 2021/10/03 20:05 | SEA Seahawks v SF 49ers | L | 28-21 |
| NFL | 2021/09/27 00:20 | GB Packers v SF 49ers | L | 30-28 |
| NFL | 2021/09/19 17:00 | SF 49ers v PHI Eagles | W | 17-11 |
| NFL | 2021/09/12 17:00 | SF 49ers v DET Lions | W | 41-33 |
| NFL Preseason | 2021/08/29 20:00 | LV Raiders v SF 49ers | W | 10-34 |
| NFL Preseason | 2021/08/22 23:30 | SF 49ers v LA Chargers | W | 15-10 |
| NFL Preseason | 2021/08/15 00:30 | KC Chiefs v SF 49ers | L | 19-16 |