Head to Head
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL Preseason | 2019/08/08 23:00 | IND Colts v BUF Bills | L | 16-24 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | W | 5-37 |
| NFL | 2017/12/10 18:00 | IND Colts v BUF Bills | L | 7-13 |
| NFL Preseason | 2016/08/13 23:00 | BUF Bills v IND Colts | W | 18-19 |
| NFL | 2015/09/13 17:00 | BUF Bills v IND Colts | L | 27-14 |
Home History
| NFL | 2021/11/14 18:00 | JAX Jaguars v IND Colts | W | 17-23 |
| NFL | 2021/11/05 00:20 | NY Jets v IND Colts | W | 30-45 |
| NFL | 2021/10/31 17:00 | TEN Titans v IND Colts | L | 34-31 |
| NFL | 2021/10/25 00:20 | IND Colts v SF 49ers | W | 30-18 |
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | W | 3-31 |
| NFL | 2021/10/12 00:15 | IND Colts v BAL Ravens | L | 25-31 |
| NFL | 2021/10/03 17:00 | IND Colts v MIA Dolphins | W | 27-17 |
| NFL | 2021/09/26 17:00 | IND Colts v TEN Titans | L | 16-25 |
Away History
| NFL | 2021/11/14 18:00 | BUF Bills v NY Jets | W | 45-17 |
| NFL | 2021/11/07 18:00 | BUF Bills v JAX Jaguars | L | 6-9 |
| NFL | 2021/10/31 17:00 | MIA Dolphins v BUF Bills | W | 11-26 |
| NFL | 2021/10/19 00:15 | BUF Bills v TEN Titans | L | 31-34 |
| NFL | 2021/10/11 00:20 | BUF Bills v KC Chiefs | W | 38-20 |
| NFL | 2021/10/03 17:00 | HOU Texans v BUF Bills | W | 0-40 |
| NFL | 2021/09/26 17:00 | WAS Commanders v BUF Bills | W | 21-43 |
| NFL | 2021/09/19 17:00 | BUF Bills v MIA Dolphins | W | 35-0 |