Home History
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | L | 41-15 |
| NFL | 2021/11/14 18:00 | BUF Bills v NY Jets | W | 45-17 |
| NFL | 2021/11/07 18:00 | BUF Bills v JAX Jaguars | L | 6-9 |
| NFL | 2021/10/31 17:00 | MIA Dolphins v BUF Bills | W | 11-26 |
| NFL | 2021/10/19 00:15 | BUF Bills v TEN Titans | L | 31-34 |
| NFL | 2021/10/11 00:20 | BUF Bills v KC Chiefs | W | 38-20 |
| NFL | 2021/10/03 17:00 | HOU Texans v BUF Bills | W | 0-40 |
| NFL | 2021/09/26 17:00 | WAS Commanders v BUF Bills | W | 21-43 |
Away History
| NFL | 2021/11/21 18:00 | NO Saints v PHI Eagles | L | 29-40 |
| NFL | 2021/11/14 18:00 | NO Saints v TEN Titans | L | 21-23 |
| NFL | 2021/11/07 18:00 | ATL Falcons v NO Saints | L | 27-25 |
| NFL | 2021/10/31 20:25 | TB Buccaneers v NO Saints | W | 27-36 |
| NFL | 2021/10/26 00:15 | NO Saints v SEA Seahawks | W | 13-10 |
| NFL | 2021/10/10 17:00 | NO Saints v WAS Commanders | W | 33-22 |
| NFL | 2021/10/03 17:00 | NY Giants v NO Saints | L | 27-21 |
| NFL | 2021/09/26 17:00 | NO Saints v NE Patriots | W | 28-13 |