[2] IND Colts 31-0 HOU Texans [3] 2021-12-05 18:00
Stadium: NRG Stadium Round: 1
Home Manager: David Culley Away Manager: Frank Reich
Head to Head
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | W | 3-31 |
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | W | 20-27 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | W | 26-20 |
| NFL | 2019/11/22 01:20 | IND Colts v HOU Texans | L | 17-20 |
| NFL | 2019/10/20 17:00 | HOU Texans v IND Colts | W | 23-30 |
| NFL | 2019/01/05 21:35 | IND Colts v HOU Texans | W | 21-7 |
| NFL | 2018/12/09 18:00 | IND Colts v HOU Texans | W | 24-21 |
| NFL | 2018/09/30 17:00 | HOU Texans v IND Colts | L | 37-34 |
Home History
| NFL | 2021/11/28 18:00 | TB Buccaneers v IND Colts | L | 38-31 |
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | W | 41-15 |
| NFL | 2021/11/14 18:00 | JAX Jaguars v IND Colts | W | 17-23 |
| NFL | 2021/11/05 00:20 | NY Jets v IND Colts | W | 30-45 |
| NFL | 2021/10/31 17:00 | TEN Titans v IND Colts | L | 34-31 |
| NFL | 2021/10/25 00:20 | IND Colts v SF 49ers | W | 30-18 |
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | W | 3-31 |
| NFL | 2021/10/12 00:15 | IND Colts v BAL Ravens | L | 25-31 |
Away History
| NFL | 2021/11/28 18:00 | NY Jets v HOU Texans | L | 21-14 |
| NFL | 2021/11/21 18:00 | HOU Texans v TEN Titans | W | 22-13 |
| NFL | 2021/11/07 18:00 | HOU Texans v MIA Dolphins | L | 9-17 |
| NFL | 2021/10/31 17:00 | LA Rams v HOU Texans | L | 38-22 |
| NFL | 2021/10/24 20:25 | HOU Texans v ARZ Cardinals | L | 5-31 |
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | L | 3-31 |
| NFL | 2021/10/10 17:00 | NE Patriots v HOU Texans | L | 25-22 |
| NFL | 2021/10/03 17:00 | HOU Texans v BUF Bills | L | 0-40 |