Head to Head
| NFL | 2018/11/04 18:00 | CHI Bears v BUF Bills | L | 41-9 |
| NFL Preseason | 2018/08/31 00:00 | BUF Bills v CHI Bears | W | 28-27 |
| NFL | 2014/09/07 17:00 | CHI Bears v BUF Bills | W | 20-23 |
Home History
| NFL Preseason | 2021/08/13 23:00 | BUF Bills v DET Lions | W | 16-15 |
| NFL | 2021/01/24 23:40 | BUF Bills v KC Chiefs | L | 24-38 |
| NFL | 2021/01/17 01:15 | BAL Ravens v BUF Bills | W | 3-17 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | W | 24-27 |
| NFL | 2021/01/03 18:00 | MIA Dolphins v BUF Bills | W | 26-56 |
| NFL | 2020/12/29 01:15 | BUF Bills v NE Patriots | W | 38-9 |
| NFL | 2020/12/19 21:30 | BUF Bills v DEN Broncos | W | 48-19 |
| NFL | 2020/12/14 01:20 | PIT Steelers v BUF Bills | W | 15-26 |
Away History
| NFL Preseason | 2021/08/14 17:00 | MIA Dolphins v CHI Bears | W | 13-20 |
| NFL | 2021/01/10 21:40 | CHI Bears v NO Saints | L | 9-21 |
| NFL | 2021/01/03 21:25 | GB Packers v CHI Bears | L | 35-16 |
| NFL | 2020/12/27 18:00 | CHI Bears v JAX Jaguars | W | 41-17 |
| NFL | 2020/12/20 18:00 | CHI Bears v MIN Vikings | W | 33-27 |
| NFL | 2020/12/13 18:00 | HOU Texans v CHI Bears | W | 7-36 |
| NFL | 2020/12/06 18:00 | DET Lions v CHI Bears | L | 34-30 |
| NFL | 2020/11/30 01:20 | CHI Bears v GB Packers | L | 25-41 |