[47] Reilly Opelka 4-6,4-6 Rafael Nadal [3] 2021-05-15 13:50
Stadium: Center Court Round: 28 Ground: Clay
Home History
| ATP Rome | 2021/05/14 08:00 | Federico Delbonis v Reilly Opelka | 5-7,6-7 |
| ATP Rome | 2021/05/13 08:00 | Reilly Opelka v Aslan Karatsev | 7-6,6-4 |
| ATP Rome | 2021/05/11 11:10 | Lorenzo Musetti v Reilly Opelka | 4-6,4-6 |
| ATP Rome | 2021/05/09 13:30 | Richard Gasquet v Reilly Opelka | 1-6,5-7 |
| ATP Madrid | 2021/05/03 10:50 | Dominik Koepfer v Reilly Opelka | 6-4,6-4 |
| ATP Miami | 2021/03/26 15:00 | Alexei Popyrin v Reilly Opelka | 6-4,6-2 |
| ATP Dubai | 2021/03/14 10:00 | Kei Nishikori v Reilly Opelka | 3-6,6-3,6-4 |
| ATP Doha | 2021/03/08 16:30 | Reilly Opelka v Roberto Bautista-Agut | 6-4,3-6,4-6 |
Away History
| ATP Rome | 2021/05/14 10:00 | Alexander Zverev v Rafael Nadal | 3-6,4-6 |
| ATP Rome | 2021/05/13 12:00 | Denis Shapovalov v Rafael Nadal | 6-3,4-6,6-7 |
| ATP Rome | 2021/05/12 16:55 | Jannik Sinner v Rafael Nadal | 5-7,4-6 |
| ATP Madrid | 2021/05/07 13:15 | Rafael Nadal v Alexander Zverev | 4-6,4-6 |
| ATP Madrid | 2021/05/06 13:00 | Rafael Nadal v Alexei Popyrin | 6-3,6-3 |
| ATP Madrid | 2021/05/05 13:40 | Rafael Nadal v Carlos Alcaraz Garfia | 6-1,6-2 |
| ATP Barcelona | 2021/04/25 14:00 | Rafael Nadal v Stefanos Tsitsipas | 6-4,6-7,7-5 |
| ATP Barcelona | 2021/04/24 14:00 | Rafael Nadal v Pablo Carreno Busta | 6-3,6-2 |