[8] Serena Williams 6-7,2-6 Katerina Siniakova [68] 2021-05-18 13:15
Stadium: Center Court Round: 26 Ground: Clay
Home History
| WTA Parma | 2021/05/17 10:40 | Serena Williams v Lisa Pigato | 6-3,6-2 |
| WTA Rome | 2021/05/12 12:50 | Serena Williams v Nadia Podoroska | 6-7,5-7 |
| Australian Open Women | 2021/02/18 03:00 | Naomi Osaka v Serena Williams | 6-3,6-4 |
| Australian Open Women | 2021/02/16 08:00 | Serena Williams v Simona Halep | 6-3,6-3 |
| Australian Open Women | 2021/02/14 02:15 | Aryna Sabalenka v Serena Williams | 4-6,6-2,4-6 |
| Australian Open Women | 2021/02/12 02:00 | Anastasia Potapova v Serena Williams | 6-7,2-6 |
| Australian Open Women | 2021/02/10 02:00 | Nina Stojanovic v Serena Williams | 3-6,0-6 |
| Australian Open Women | 2021/02/08 01:30 | Laura Siegemund v Serena Williams | 1-6,1-6 |
Away History
| WTA Parma | 2021/05/17 09:00 | Katerina Siniakova v Clara Tauson | 6-1,6-3 |
| WTA Madrid | 2021/04/27 08:00 | Katerina Siniakova v Ana Bogdan | 6-7,5-7 |
| WTA Istanbul | 2021/04/23 14:20 | Elise Mertens v Katerina Siniakova | 6-4,6-4 |
| WTA Istanbul | 2021/04/21 16:00 | Katerina Siniakova v Kristina Mladenovic | 6-4,3-6,6-4 |
| WTA Istanbul | 2021/04/19 09:00 | Katerina Siniakova v Cristina Bucsa | 7-6,3-6,6-3 |
| WTA Miami | 2021/03/24 15:00 | Katerina Siniakova v Ana Konjuh | 6-7,5-7 |
| WTA St. Petersburg | 2021/03/18 10:00 | Katerina Siniakova v Margarita Betova | 4-6,4-6 |
| WTA St. Petersburg | 2021/03/16 14:10 | Katerina Siniakova v Kirsten Flipkens | 6-1,6-2 |