[161] Illya Marchenko 5-7,6-7 Frances Tiafoe [74] 2021-06-09 16:50
Stadium: Court 1 Round: 26 Ground: Hardcourt indoor
Home History
| Challenger Nottingham | 2021/06/08 10:40 | Federico Gaio v Illya Marchenko | 2-6,3-6 |
| French Open | 2021/05/27 12:10 | Illya Marchenko v Botic Van De Zandschulp | 1-6,2-6 |
| French Open | 2021/05/26 10:45 | Andrey Kuznetsov v Illya Marchenko | 6-3,4-6,3-6 |
| French Open | 2021/05/24 16:05 | Brayden Schnur v Illya Marchenko | 7-6,5-7,4-6 |
| ATP Geneva | 2021/05/15 10:00 | Marco Cecchinato v Illya Marchenko | 6-3,6-4 |
| Challenger Heilbronn | 2021/05/10 11:25 | Illya Marchenko v Bernabe Zapata Miralles | 3-6,6-7 |
| Challenger Prague | 2021/05/04 10:50 | Vit Kopriva v Illya Marchenko | 6-2,6-7,7-6 |
| ATP Barcelona | 2021/04/17 13:25 | Illya Marchenko v Sumit Nagal | 6-3,2-6,5-7 |
Away History
| Challenger Nottingham | 2021/06/07 11:00 | Marc-Andrea Huesler v Frances Tiafoe | 3-6,4-6 |
| French Open | 2021/05/31 09:00 | Steve Johnson v Frances Tiafoe | 6-7,3-6,6-4,6-2,6-1 |
| ATP Rome | 2021/05/08 11:05 | Frances Tiafoe v Jozef Kovalik | 6-2,7-5 |
| ATP Madrid | 2021/05/01 10:35 | Frances Tiafoe v Marco Cecchinato | 6-7,2-6 |
| ATP Estoril | 2021/04/26 15:15 | Kevin Anderson v Frances Tiafoe | 4-6,7-6,7-6 |
| ATP Barcelona | 2021/04/21 16:45 | Diego Schwartzman v Frances Tiafoe | 3-6,7-5,6-1 |
| ATP Barcelona | 2021/04/20 13:55 | Carlos Alcaraz Garfia v Frances Tiafoe | 4-6,6-7 |
| ATP Miami | 2021/03/30 20:20 | Daniil Medvedev v Frances Tiafoe | 6-4,6-3 |