[1] FC Brno 2-1 Sparta Prague B [2] 2021-10-01 15:00
Stadium: Mestsky Fotbalovy Stadion Srbska Round: 10
Referee: Tomas Batik Home Manager: Richard Dostalek Away Manager: Michal Hornak
Home History
| Czech Republic 2. Liga | 2021/09/24 16:00 | FK Usti nad Labem v FC Brno | W | 1-6 |
| Czech Republic 2. Liga | 2021/09/19 18:00 | FC Brno v Viktoria Zizkov | W | 2-1 |
| Czech Republic 2. Liga | 2021/09/10 15:00 | FK Pribram v FC Brno | W | 0-1 |
| Czech Republic 2. Liga | 2021/08/29 18:00 | FC Brno v Varnsdorf | D | 2-2 |
| Czech Republic Cup | 2021/08/25 15:00 | Hanacka Slavia Kromeriz v FC Brno | W | 6-7 |
| Czech Republic 2. Liga | 2021/08/22 08:15 | SK Lisen v FC Brno | W | 1-2 |
| Czech Republic 2. Liga | 2021/08/15 18:00 | FC Brno v Vysocina Jihlava | W | 4-0 |
| Czech Republic Cup | 2021/08/11 16:00 | Zdar nad Sazavou v FC Brno | W | 0-4 |
Away History
| Czech Republic 2. Liga | 2021/09/26 08:30 | Sparta Prague B v FC Sellier & Bellot Vlasim | L | 2-3 |
| Czech Republic 2. Liga | 2021/09/18 08:15 | MFK Vyskov v Sparta Prague B | W | 2-3 |
| Czech Republic 2. Liga | 2021/09/12 08:30 | Sparta Prague B v FK Usti nad Labem | W | 1-0 |
| Czech Republic 2. Liga | 2021/08/29 08:30 | Sparta Prague B v FC Silon Taborsko | W | 4-1 |
| Czech Republic 2. Liga | 2021/08/21 15:00 | FK Pribram v Sparta Prague B | W | 0-2 |
| Czech Republic 2. Liga | 2021/08/15 08:30 | Sparta Prague B v Viktoria Zizkov | L | 0-3 |
| Czech Republic 2. Liga | 2021/08/08 15:00 | Varnsdorf v Sparta Prague B | L | 3-1 |
| Czech Republic 2. Liga | 2021/08/01 08:30 | Sparta Prague B v SK Prostejov | W | 4-0 |