Stadium: Seibert Stadium Round: 1
Home Manager: Chris Hatcher Away Manager: Dewayne Alexander
| NCAAF | 2021/04/11 20:00 | Tennessee Tech v Tennessee Martin | L | 7-40 |
| NCAAF | 2021/04/03 18:30 | Tennessee State v Tennessee Tech | W | 10-24 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri St | L | 21-24 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | L | 20-28 |
| NCAAF | 2021/03/14 18:30 | Murray State v Tennessee Tech | L | 36-31 |
| NCAAF | 2021/02/28 21:00 | Tennessee Tech v Jacksonville State | L | 10-27 |
| NCAAF | 2021/02/21 19:30 | Austin Peay v Tennessee Tech | W | 21-27 |
| NCAAF | 2019/11/23 19:30 | Tennessee State v Tennessee Tech | L | 37-27 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford | W | 20-44 |
| NCAAF | 2021/03/27 17:00 | Samford v The Citadel | W | 55-7 |
| NCAAF | 2021/03/20 17:00 | VMI v Samford | L | 38-37 |
| NCAAF | 2021/03/13 18:00 | Wofford v Samford | W | 31-37 |
| NCAAF | 2021/03/06 18:00 | Samford v Furman | L | 37-44 |
| NCAAF | 2021/02/27 18:00 | Western Carolina v Samford | W | 27-55 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | L | 17-24 |
| NCAAF | 2019/11/23 17:00 | Samford v Auburn | L | 0-52 |